Protamine sulfate, 10 mg/ml 5 pcs 5 pcs

Protamine sulfate is a specific heparin antagonist. 1 mg of protamine sulfate neutralizes 80 – 120 units of heparin in blood.

The complexation is due to the abundance of cationic groups (due to arginine) that bind to the anionic centers of heparin.

The action of the drug after intravenous administration occurs immediately and lasts for 2 hours. After intravenous administration a protamine-heparin complex is formed which may break down with release of heparin.

In overdose, it may decrease blood clotting because protamine sulfate itself has anticoagulant activity.

Indications

Bleeding due to heparin overdose;
before surgery in patients taking heparin for therapeutic purposes;
after operations on the heart and blood vessels with extracorporeal circulation;
hyperheparinemia.

Pharmacological effect

Protamine sulfate is a specific heparin antagonist. 1 mg of protamine sulfate neutralizes 80–120 units of heparin in the blood.

Complex formation is due to the abundance of cationic groups (due to arginine), which bind to the anionic centers of heparin.

The effect of the drug after intravenous administration occurs instantly and lasts for 2 hours. After intravenous administration, a protamine-heparin complex is formed, which can be destroyed to release heparin.

In case of overdose, it can reduce blood clotting, because Protamine sulfate itself exhibits anticoagulant activity.

Special instructions

The administration is carried out under the control of blood clotting. Before administration, you should ensure that the patient’s blood volume is adequate (hypovolemia increases the risk of collapse).

Active ingredient

Protamine sulfate

Composition

Solution for injection 1 ml protamine sulfate 10 mg

Contraindications

Hypersensitivity to the components of the drug;
idiopathic or congenital hyperheparinemia (in such cases the drug is not effective and may increase bleeding);
severe arterial hypotension;
thrombocytopenia;
adrenal insufficiency;
patients taking insulin containing protamine sulfate, as well as other medications containing protamine sulfate;
history of allergic reactions to fish.

Side Effects

From the cardiovascular system: decreased blood pressure, bradycardia.

From the digestive system: nausea, vomiting.

From the immune system: skin rash, itching, development of anaphylactoid reactions.

Other: feeling of heat, skin flushing, feeling of lack of air (with excessively rapid administration).

Interaction

Incompatible with cephalosporin solutions and penicillin (do not administer simultaneously). There is no data on interaction with other drugs.

Overdose

May be accompanied by bleeding, because Protamine has its own anticoagulant activity.

Treatment is symptomatic.

Interaction with other drugs

Incompatible with cephalosporins and penicillins.

It is an antagonist of low molecular weight heparins. May increase the intensity and duration of action of non-depolarizing muscle relaxants.

Manufacturer

Ellara LLC, Russia