Polyoxidonium, lyophilizate 3 mg 5 ml 5 pcs

How to take, the dosage

Ways of administration and doses for adults

Methods of administration of Polioxidonium®: parenteral, intranasal. The method of administration is chosen by a doctor, depending on the severity of the disease and the age of the patient.

Intramuscularly or intravenously (drops): The drug is given to adults in doses of 6-12 mg once a day, every other day, or once or twice a week depending on the diagnosis and severity of the disease.

For intramuscular administration the contents of the ampoule or vial are dissolved in 1.5-2 ml of 0.9% sodium chloride solution or water for injection. For intravenous (drip) administration the drug is dissolved in 2 ml of 0.9% sodium chloride solution, Hemodez-N,

Reopolyglucin or 5% dextrose solution, then sterilely transferred into a bottle with the above solutions of 200-400 ml volume.

The prepared solution for parenteral administration should not be stored.

Intranasally: a dose of 6 mg is dissolved in 1 ml (20 drops) of distilled water, 0.9% sodium chloride solution or boiled water at room temperature.

Recommended treatment regimen for adults

Parenterally:

In acute inflammatory diseases: 6 mg daily for 3 days, then every other day for a total course of 5-10 injections.

In chronic inflammatory diseases: 6 mg every other day for 5 injections, then 2 times a week for a course of at least 10 injections.

In case of tuberculosis: 6-12 mg 2 times a week for a course of 10-20 injections.

In patients with acute and chronic urogenital diseases: 6 mg every other day for a course of 10 injections in combination with chemotherapy.

In patients with chronic recurrent herpes: 6 mg every other day and 10 injections in combination with antiviral drugs, interferons and/or interferon synthesis inducers.

For the treatment of complicated forms of allergic diseases: 6 mg, course of 5 injections: the first two injections daily, then every other day. In acute allergic and toxic-allergic states it is administered intravenously with 6-12 mg in combination with antiallergic drugs.

In rheumatoid arthritis: 6 mg 5 injections every other day, then 2 times a week for a course of at least 10 injections.

In cancer patients:

– before and against the background of chemotherapy to reduce the immunosuppressive, hepato- and nephrotoxic effects of chemotherapeutic agents: 6-12 mg every other day for a course of at least 10 injections; further the frequency of administration is determined by the doctor depending on tolerance and duration of chemotherapy and radiation therapy;

In order to prevent immunosuppressive effects of the tumor, to correct immunodeficiency after chemotherapy and radiation therapy, after surgical removal of a tumor, long-term administration of Polioxidonium® (from 2-3 months to 1 year) 6-12 mg weekly, 1-2 times.

In patients with acute renal failure, it is prescribed not more than 2 times a week.

Inntranasally 6 mg daily is administered for treatment of acute and chronic ENT-organ infections; for strengthening of regenerative processes of mucous membranes, for prevention of disease complications and relapses and for prevention of flu and acute respiratory diseases. 3 drops in each nostril every 2-3 hours (3 times a day) for 5-10 days.

Ways of administration and doses for children

Ways of administration of Polioxidonium®: parenterally, intranasally, sublingually. The method of administration is chosen by the doctor depending on the diagnosis, severity of the disease, age and body weight of the patient.

Parenterally the drug is prescribed to children from 6 months old in a dose of 3 mg (intramuscularly or intravenously in a 0.1-0.15 mg/kg drop) daily, every other day or twice a week for a course of 5-10 injections (the table shows the dose calculation).

For intramuscular administration the drug is dissolved in 1 ml of water for injection or 0.9% sodium chloride solution.

For intravenous drops the drug is dissolved in 1.5-2 ml of sterile 0.9% solution of sodium chloride, Reopolyglucin, Hemodez-N or 5% solution of dextrose; the drug is sterile transferred into a bottle with the above solutions of 150-250 ml volume.

Intranasally and sublingually: daily in a daily dose of 0.15 mg/kg for 5-10 days. The drug is administered in 1-3 drops in one nasal passage or under the tongue after 2-3 hours.

The solution for sublingual and intranasal use should be kept in refrigerator for not more than 7 days. Before use the pipette with the solution must be warmed up to room temperature (20-25 oC).

Recommended regimen for treatment of children

– In acute inflammatory diseases: 0.1 mg/kg every other day for 5-7 injections.

In chronic inflammatory diseases: 0.15 mg/kg 2 times a week for up to 10 injections.

– In acute allergic and toxic-allergic conditions: intravenous drops at a dose of 0.15 mg/kg in combination with antiallergic drugs.

– For treatment of complicated forms of allergic diseases in combination with basic therapy: intramuscularly 0.1 mg/kg for a course of 5 injections with intervals of 1-2 days.

Intranasally administer 1-3 drops in one nasal passage every 2-3 hours (2-4 times a day). For intranasal and sublingual administration, the calculation of the daily dose for children is shown in the table.

5 kg – 5 drops 0.25 ml

10 kg – 10 drops 0.5 ml

15 kg – 15 drops 0.75 ml

20 kg – 20 drops 1.00 ml

Sublingually: For all indications, daily at a daily dose of 0.15 mg/kg for 10 days, for the treatment of gut dysbacteriosis for 10-20 days. Drip 1-3 drops under the tongue after 2-3 hours.

Interaction

Polioxidonium® is compatible with antibiotics, antiviral, antifungal and antihistamines, bronchodilators, glucocorticosteroids and cytostatics.

Special Instructions

In case of pain at the injection site the drug is dissolved in 1 ml of 0.25% procaine solution if the patient has no individual hypersensitivity to procaine.

Contraindications

Individual hypersensitivity. Pregnancy, lactation (no clinical experience of use).

WARNING

Acute renal failure, children under 6 months of age (clinical experience is limited).

Side effects

Possible pain at the injection site when injected intramuscularly.

Overdose

At the present time, no cases of overdose of Polioxidonium® have been reported.

Pregnancy use

Polioxidonium is contraindicated in pregnancy, lactation and children under 6 months of age (no clinical experience of use).

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