Polyglucin, 6%, 200 ml

Pharmacodynamics Blood substitute, hyperosmotic solution with osmolarity 0.34-0.37 mmol/kg. It has plasma exchange, antishock, replenishing circulating blood volume and anti-aggregant effect.

Indications

Restoration of water-salt balance hypovolemic shock (severe posthemorrhagic hypovolemia, blood loss during childbirth, as a result of ectopic pregnancy, etc.); traumatic shock (surgical shock); burn shock; compression syndrome; septic shock, shock due to intoxication; violation of microcirculation (capillary blood flow), rheological properties of blood; pre- and postoperative prevention of embolism; prevention of thrombophlebitis; for filling the machines of artificial circulation (in certain proportions with blood).

Active ingredient

Dextran

How to take, the dosage

High-molecular-weight dextran solutions are administered by IV at a rate of 60-80 drops per minute in an amount of up to 2-2.5 liters (with additional blood administration in case of significant blood loss).

Low molecular weight dextran solutions when used as a blood substitute are usually administered in the same doses. In other cases, the daily dose should not exceed 20 ml/kg. The rate of IV infusion is determined by the indication and the severity of the patient’s condition.

Dextran with a molecular weight of 1000 is administered by IV (IV) stream to adults in a dose of 3 g (20 ml), in children – in a dose of 45 mg/kg (0.3 ml/kg) – 1-2 minutes before the IV infusion of dextran solution. The interval between the injection of dextran with molecular weight 1000 and infusion of dextran solution should not exceed 15 min. If more than 15 min have elapsed, dextran with molecular weight 1000 should be re-injected. It may be administered before each infusion of dextran solution, especially if more than 48 h have elapsed since the previous infusion.

Interaction

Polyglucin must not be used as a solvent for other drugs (possible unfavorable physical and chemical interactions).

Special Instructions

Due to possible allergic reactions, it is recommended to administer the first 10-20 ml of the infusion solution slowly, observing the patient’s condition. Given the possibility of arterial hypertension, it should be borne in mind that appropriate means for intensive therapy may be required.

Dextran with a molecular weight of 1000 should not be diluted or mixed with dextran solutions for infusion. Dextran with a molecular weight of 1000 may be administered intravenously through the Y-tap or rubber tubing of an infusion system, provided there is no significant dilution of the drug during injection.

Contraindications

Hypersensitivity, cardiovascular insufficiency, ongoing internal bleeding, craniocerebral trauma, intracranial hypertension, hemorrhagic stroke, anuria, severe chronic renal failure, thrombocytopenia, clinical situations in which large volumes of fluids should not be administered (including arterial hypertension, hyperkalemia against hematocrit values below 0.3).

Side effects

Possible: allergic reactions.

Rarely: arterial hypotension.

Overdose

Excessive BP elevation is possible, and peripheral vasodilators are administered to normalize it

Similarities

Reopolyglucin