Phenibut, tablets 250 mg 30 pcs

Pharmacotherapeutic group: Other psychostimulants and nootropic agents.

AtХ code: N06BX22.

Pharmacological properties

Pharmacodynamics

. As a derivative of gamma-aminobutyric acid and phenylethylamine, aminophenyl butyric acid facilitates GABA-mediated transmission of nerve impulses in the central nervous system (direct effect on GABA-ergic receptors). It has tranquilizing effect that is combined with stimulating central nervous system activity: it improves functional condition of the brain by normalizing its metabolism and blood flow in the brain (increases volume and linear velocity of blood flow, reduces vascular resistance and improves microcirculation), reduces vasovaginal symptoms (including headache and “heavy” feeling in the head, sleep disorders, irritability, emotional lability), eliminates psycho-emotional tension, contributes to the development of the brain, and improves blood circulation.

Does not affect the choline and adrenoreceptors. It prolongs the latent period and shortens the duration and severity of nystagmus. With a course of treatment it increases physical and mental performance (improves attention, memory, speed and accuracy of sensory-motor reactions). It reduces manifestations of asthenia, increases interest and initiative (promotes motivation to activity) without the effects of sedation or agitation.

In the elderly it does not cause central nervous system depression, muscular relaxation effects are most often absent.

Limits the depressing effects of ethanol on the central nervous system.

Pharmacokinetics

Adsorption after oral administration is high; the drug well penetrates into all body tissues and through blood-brain barrier (about 0.1% of administration dose penetrates into brain tissue, and in younger and elderly people the degree of penetration into the brain may increase). 80-95% of the drug is metabolized in the liver; the metabolites are pharmacologically inactive. It does not accumulate in the body, including when administered repeatedly. It is eliminated by the kidneys after 3 hours, and its concentration in brain tissue is not decreased, and aminophenyl butyric acid is detected in the brain for another 6 hours. About 5% of the taken dose of the drug is excreted unchanged by the kidneys, partially excreted in the bile.

Indications

Active ingredient

Composition

How to take, the dosage

Interaction

Special Instructions

Synopsis

Contraindications

Side effects

Overdose

Pregnancy use

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