Paracetamol-Altpharm, rectal 50 mg 10 pcs
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analgesic non-narcotic agent
Pharmacodynamics:Paracetamol has antipyretic and analgesic effect. The drug blocks cyclooxygenase 1 and 2 in CNS affecting the centers of pain and thermoregulation. In inflamed tissues, cellular pyroxidases neutralize the effect of paracetamol on cyclooxygenase, which explains the almost complete absence of anti-inflammatory effect of the drug. The absence of blocking effect on prostaglandin synthesis in peripheral tissues determines the absence of its negative effect on water-salt metabolism (Na+ and water retention) and erosive-ulcerative lesions of the gastrointestinal mucosa. Pharmacokinetics:
Paracetamol is rapidly and almost completely absorbed from the gastrointestinal tract. The maximum concentration of paracetamol in the blood is reached 16 – 28 hours after administration of the drug and is 26 – 56 mg/liter. When rectal administration the completeness of paracetamol absorption is lower than after oral administration.
Paracetamol is quickly and evenly distributed throughout the body tissues. With plasma proteins 10 – 15% of the taken dose is bound. Amount of distribution and bioavailability are not significantly different in children and adults. The drug penetrates through the blood-brain and placental barriers. Less than 1% of the administered dose goes into the breast milk of nursing mothers.
Paracetamol is metabolized by microsomal liver enzymes. About 80% forms conjugates with glucuronic acid and sulfates to 17% undergoes hydroxylation to form active metabolites that conjugate with glutathione. In overdose or lack of glutathione these metabolites can cause necrosis of hepatocytes.
The half-life of paracetamol is 20-40 hours. It may increase in patients with severe liver dysfunction and elderly patients. Twenty-four hours after taking it, 85-90% of paracetamol is excreted in the urine as glucoronides and sulphates; 3% of it remains unchanged.
In children under 10 – 12 years of age, the formation of conjugates with sulfates is the main route of metabolism and excretion of paracetamol. The likelihood of hepatotoxic effects in children is lower than in adults. Other pharmacokinetic parameters of adults and children do not differ.
Indications
Toothache, Flu, Pain, Headache
The drug is recommended for adults and children from 1 month of life (for children from 1 to 3 months of life – as prescribed by the doctor):
– As antipyretic in acute respiratory diseases influenza childhood infections post-vaccination reactions and other infectious and inflammatory diseases accompanied by fever.
A pain reliever in mild to moderate levels of pain including: headache and toothache muscle pain arthralgia neuralgia algodysmenorrhea pain in injuries and burns.
Active ingredient
Paracetamol
Composition
Composition per 1 suppository:
The active substance: paracetamol – 0.05 g, 0.10 g, 0.25 g or 0.5 g.
Auxiliary substance: fatty acids glycerides (solid fat) – 0.75 g, 0.90 g, 0.75 g or 0.60 g.
How to take, the dosage
Dosage for adults and adolescents over 15 years:
The average single dose is 500 mg 1-4 times a day, the maximum single dose is 1 g (2 suppositories of 500 mg), the maximum daily dose is 4 g.
Dosage for children:
It depends on the age and body weight of the child. The recommended single dose of paracetamol is 10-15 mg/kg of child body weight. The frequency of administration is 1-4 times a day with an interval of at least 4 hours. The maximum daily dose is not more than 60 mg/kg of child’s body weight.
Example dosage schedule for suppositories in children depending on their age:
Age of child | Disposable dose | Daily dose | ||
1 – 3 months. | 50 mg (as recommended by physician) | |||
3 – 6 months. | 50 mg | 150 mg | ||
6 – 12 months. | 50 mg – 100 mg | 150 mg – 200 mg | 1 – 2 years | 50 – 100 mg | 200 mg – 300 mg < |
2 – 6 years | 100 – 250 mg | 300 mg – 600 mg | ||
6 – 8 years | 250 mg | 500 mg – 750 mg | ||
8 – 12 years | 250 mg | 750 mg | ||
12 – 15 years | 250 mg | 750 mg – 1000 mg |
Weight | 0.020 kg |
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Shelf life | 2 years. Do not use after the expiration date printed on the package. |
Conditions of storage | Store in a light-protected place at a temperature not exceeding 25 °С. Keep out of reach of children. |
Manufacturer | Altfarm, Russia |
Medication form | rectal suppositories |
Brand | Altfarm |
Other forms…
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