Pantocalcin, tablets 500 mg 50 pcs

Pharmacodynamics

The spectrum of action is associated with the presence of gamma-aminobutyric acid in the structure. The mechanism of action is due to the direct effect of pantocalcin on GABA-receptor-channel complex. It has neurometabolic, neuroprotective and neurotrophic properties. Increases resistance of the brain to hypoxia and toxic substances, stimulates anabolic processes in neurons. It has anticonvulsant effect, reduces motor excitability with simultaneous ordering of behavior. Increases mental and physical performance.

It promotes normalization of gamma-aminobutyric acid in chronic alcohol intoxication and subsequent withdrawal of ethanol. It shows analgesic effect. It is able to inhibit acetylation reactions participating in mechanisms of inactivation of novocaine and sulfonamides; due to this it is possible to achieve prolongation of the action of the latter. It causes inhibition of pathologically increased bladder reflex and detrusor tone.

Pharmacokinetics

It is rapidly absorbed in the gastrointestinal tract. Time of reaching maximum concentration in blood plasma is 1 h. The highest concentrations are formed in the liver, kidneys, gastric wall, skin. It penetrates through blood-brain barrier.

It is not metabolized. It is excreted unchanged during 48 hours (67.5% of dose – in the urine, 28.5% – in the faeces).

Indications

Children:

Active ingredient

Composition

1 tablet contains:
active ingredient:
hopanthenic acid – 250.00 mg or 500.00 mg;
excipients:
magnesium hydroxycarbonate, calcium stearate, talc, potato starch.

How to take, the dosage

Ingestion.

Take 15-30 minutes after a meal.

A single dose for adults is 0.5-1 g, for children – 0.25-0.5 g, daily dose – 1.5-3 g (for adults), 0.75-3 g (for children). Duration of treatment course – from 1 to 4 months, in some cases – up to 6 months. After 3 to 6 months it is possible to carry out the second course of treatment.

Children. Mental retardation – 0.5 g 4-6 times a day, every day for 3 months. Delayed speech development – 0.5 g 3-4 times a day for 2-3 months.

The neuroleptic syndrome (as a corrector of the side effects of neuroleptic drugs). Adults – 0.5-1 g 3 times a day; children – 0.25-0.5 g 3-4 times a day. Duration of treatment course is 1-3 months.

Epilepsy. Children – 0.25-0.5 g 3-4 times a day; adults – 0.5-1 g 3-4 times a day for a long time (up to 6 months).

Hyperkinesias (tics). Children – 0.25-0.5 g 3-6 times daily for 1-4 months; adults – 1.5-3 g daily for 1-5 months.

Disorders of urination. Adults – 0.5-1 g 2-3 times a day (daily dose – 2-3 g); children – 0.25-0.5 g (daily dose – 25-50 mg/kg). Duration of the course of treatment – from 2 weeks to 3 months (depends on the severity of the disorders and the therapeutic effect).

The consequences of neuroinfections and craniocerebral injuries. 0,25 g 3-4 times a day.

To restore performance under increased stress and asthenic conditions.0.25 g 3 times a day.

This dosage form is not recommended for children under 3 years of age.

Interaction

Synopsis

Contraindications

Side effects

Allergic reactions (rhinitis, conjunctivitis, skin rashes) are possible.

Overdose

Pregnancy use

It is contraindicated in the first trimester of pregnancy.

Similarities