Pancreatin, 125 mg 50 pcs

Pharmgroup:

Digestive enzyme agent.

Pharmaceutical action:

Digestive enzyme remedy, replenishes pancreatic enzymes deficiency, has proteolytic, amylolytic and lipolytic action. Pancreatic enzymes (lipase, alpha-amylase, trypsin, chymotrypsin) help in breakdown of proteins into amino acids, fats into glycerol and fatty acids, starch into dextrins and monosaccharides; it improves functional state of gastrointestinal tract and normalizes digestive processes.

Trypsin suppresses stimulated pancreatic secretion with analgesic effect.
Pancreatic enzymes are released from the dosage form in the alkaline environment of the small intestine, as they are protected from the action of gastric juice by a coating.

The maximum enzymatic activity of the drug is observed 30-45 min after oral administration.

Indications

Insufficiency of exocrine pancreatic function (chronic pancreatitis, cystic fibrosis, etc.).

Chronic inflammatory-dystrophic diseases of the stomach, intestines, liver, gall bladder; conditions after resection or irradiation of these organs, accompanied by impaired digestion of food, flatulence, diarrhea (as part of combination therapy.

To improve food digestion in patients with normal gastrointestinal function in cases of dietary errors.

Preparation for x-ray and ultrasound examination of the abdominal organs.

Pharmacological effect

Pharmaceutical group:

digestive enzyme agent.

Pharmaceutical action:

Digestive enzyme agent, replenishes the deficiency of pancreatic enzymes, has proteolytic, amylolytic and lipolytic effects. The pancreatic enzymes included in the composition (lipase, alpha-amylase, trypsin, chymotrypsin) promote the breakdown of proteins into amino acids, fats into glycerol and fatty acids, starch into dextrins and monosaccharides, improves the functional state of the gastrointestinal tract, and normalizes digestive processes.

Trypsin suppresses stimulated pancreatic secretion, producing an analgesic effect.
Pancreatic enzymes are released from the dosage form in the alkaline environment of the small intestine, because protected from the action of gastric juice by the membrane.

The maximum enzymatic activity of the drug is observed 30-45 minutes after oral administration.

Active ingredient

Pancreatin

Composition

1 tablet contains pancreatin – 0.125 g.

Excipients:

lactose (milk sugar),

methylcellulose MC-16,

calcium stearate,

celacephate,

acid red 2C,

titanium dioxide,

polysorbate 80.

Contraindications

Hypersensitivity to the components of the drug, acute pancreatitis, exacerbation of chronic pancreatitis, children under 6 years of age.

Side Effects

From the digestive system: in some cases – diarrhea, constipation, discomfort in the stomach, nausea. The cause-and-effect relationship between the development of these reactions and the action of pancreatin has not been established, because These phenomena refer to symptoms of exocrine pancreatic insufficiency.

Allergic reactions: in some cases – skin manifestations.

From the metabolic side: with long-term use in high doses, the development of hyperuricosuria is possible; in excessively high doses, an increase in the level of uric acid in the blood plasma.

Other: when using pancreatin in high doses in children, perianal irritation may occur.

Interaction

When used simultaneously with antacids containing calcium carbonate and/or magnesium hydroxide, the effectiveness of pancreatin may be reduced.

With simultaneous use, it is theoretically possible to reduce the clinical effectiveness of acarbose.

With simultaneous use of iron supplements, a decrease in iron absorption is possible.

Storage conditions

Store at a temperature not exceeding 15C.
Keep out of the reach of children.

Shelf life

3 years.
Do not use after the expiration date stated on the package.

Manufacturer

Pharmstandard-Leksredstva, Russia