Oraleir, 300 ir 30 pcs.
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The exact mechanism of allergen action in allergen-specific immunotherapy (ASIT) is not completely clear.
The following biological changes have been proven: The appearance of specific antibodies (IgG4), which play the role of “blocking antibodies”; a decrease in plasma levels of specific IgE for a prolonged period; a decrease in reactivity of cells involved in the allergic reaction; an increase in the activity of interaction between Th2 and Th1 and even Th0 lymphocytes, leading to a positive change in cytokine production (decrease IL-4 and increase gamma interferon) that regulates IgE production.
In addition, ASIT induces an immune response, which makes it possible to maintain immunobiological memory over a long period. The effectiveness of ASIT is higher when treatment is started early in the course of the disease.
Indications
Allergen specific immunotherapy (ASIT) for patients with type 1 allergic reactions (IgE-mediated) manifested by rhinitis or rhinoconjunctivitis with hypersensitivity to pollen of meadow grasses (common hedgehog, common spikelet, perennial chaff, meadow bluegrass, meadow thymothea), confirmed by positive results in skin testing and/or increased content of specific lgE. Immunotherapy can be given to adults and children from the age of 5 years.
Active ingredient
Composition
Active ingredient:
Allergen extract from a mixture of grass pollen (hedgehog, common spikelet, perennial spikelet, meadow bluegrass, meadow timothy) in equal proportions of 100 IR and 300 IR;
Auxiliary substances:
Microcrystalline cellulose – 12.5 mg,
croscarmellose sodium – 2.5 mg,
Colloid silica – 0.5 mg,
Magnesium stearate – 0.7 mg,
Lactose monohydrate – up to 100 mg
How to take, the dosage
Treatment with the drug should be carried out by an allergist.
If the drug is used in pediatric practice, the physician should have appropriate experience in treating children. It is recommended that the first tablet be taken under the supervision of a physician to monitor the patient’s condition for 30 minutes.
The treatment should be started 4 months before the anticipated flowering season, continued throughout the dusting season and discontinued with the end of the season.
The drug is recommended to be taken in the morning on an empty stomach. The tablet should be placed under the tongue and held until completely dissolved (for at least 1 minute), then swallowed.
Breaks in taking the drug should be avoided. The dose should not be increased after a drug skip. If the missed dose is less than 7 days, it is recommended to resume taking the drug in the same dose at which the treatment was interrupted and follow the recommended regimen.
If prolonged absences (more than 7 days) are missed, the physician should be consulted.
Special Instructions
In case of surgical operations in the oral cavity (including removal of tubes) the therapy should be interrupted until complete recovery (at least for 7 days).
In case of severe allergic reactions the doctor may recommend taking epinephrine. It should be noted that patients taking tricyclic antidepressants, monoamine oxidase inhibitors have an increased risk of side effects to its administration up to fatal outcome.
There is no clinical experience of concomitant vaccination and treatment with the drug. Vaccination should only be carried out after consultation with a doctor.
The drug does not affect the ability to drive vehicles and mechanisms.
Contraindications
Side effects
Immune system disorders: allergic reactions.
CNS and peripheral nervous system disorders: headache, dizziness, altered sense of taste, paresthesia.
An organ of vision: conjunctivitis, hyperemia.
Hearing organ: itching of the ears, congestion of the ear.
Respiratory system: irritation in the throat, difficulty breathing, swelling, rhinitis symptoms, sore throat, coughing, choking, dysphonia.
Gastrointestinal tract: itching, swelling, inflammation, numbness, tingling sensation in the mouth, increased salivation, dry mouth, lips, vesicular rash in the mouth, on the lips, glossodynia, gastrointestinal disorders, inflammation in the gastrointestinal tract.
Skin and subcutaneous tissue: facial swelling, itching, urticaria, angioedema, eczema.
General disorders: fatigue, anxiety.
Weight | 0.015 kg |
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Conditions of storage | Keep out of reach of children, at a temperature not exceeding 25 C. |
Manufacturer | Senexie, France |
Medication form | sublingual tablets |
Brand | Senexie |
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