Ondansetron-Altfarm, rectal 16 g mg 2 pcs
€20.54 €17.11
Ondansetron is a selective 5HTH3 (serotonin) receptor antagonist.
The drugs for cytostatic chemotherapy and radiotherapy can cause increased levels of serotonin, which by activation of vagal afferent fibers containing 5-HT3 receptors, causes the gag reflex.
Ondansetron inhibits the onset of the gag reflex by blockade of 5-NT3 receptors at the neuronal level of both the central and peripheral nervous system.
Apparently this mechanism of action is the basis for the prevention and treatment of postoperative and cytostatic chemo- and radiotherapy-induced vomiting and nausea.
Indications
Prevention of nausea and vomiting during antitumor chemotherapy or radiation therapy;
prevention and treatment of nausea and vomiting in the postoperative period.
Pharmacological effect
Ondansetron is a selective 5HT3 (serotonin) receptor antagonist.
Cytostatic chemotherapy drugs and radiotherapy can cause an increase in serotonin levels, which, by activating vagal afferent fibers containing 5-HT3 receptors, causes the gag reflex.
Ondansetron inhibits the appearance of the gag reflex by blocking 5-HT3 receptors at the level of neurons in both the central and peripheral nervous systems.
Apparently, this mechanism of action is the basis for the prevention and treatment of postoperative vomiting and nausea caused by cytostatic chemotherapy and radiotherapy.
Active ingredient
Ondansetron
Composition
1 suppository contains:
Active substance:
ondansetron hydrochloride 16 mg;
Excipients:
Witepsol N-15.
Contraindications
Hypersensitivity, children’s age – for rectal administration (up to 2 years – for oral and parenteral administration).
Side Effects
From the gastrointestinal tract: constipation/diarrhea, dry mouth, hiccups, transient increase in AST and ALT levels.
From the nervous system and sensory organs: headache, dizziness, spontaneous movement disorders and convulsions, impaired visual acuity, extrapyramidal disorders (with parenteral use).
From the cardiovascular system and blood (hematopoiesis, hemostasis): fainting, chest pain, in some cases with ST segment depression, bradycardia, arrhythmia, arterial hypotension.
Allergic reactions: urticaria, bronchospasm, laryngospasm, angioedema, anaphylaxis.
Other: fever, sensation of heat, flushing, hypokalemia, hypercreatinemia, local reactions (pain, redness and burning at the injection site); burning in the anus and rectum (suppositories).
Storage conditions
In a dry place, protected from light, at a temperature not exceeding 25 °C
Shelf life
2 years
Manufacturer
Altfarm, Russia
Shelf life | 2 years |
---|---|
Conditions of storage | In a dry, light-protected place at a temperature not exceeding 25 °C |
Manufacturer | Altfarm, Russia |
Medication form | rectal suppositories |
Brand | Altfarm |
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