OKI, 150 ml

Pharmacotherapeutic group

Other oral medications.

TAC code: A01AD11.

Pharmacodynamics

It has anti-inflammatory, analgesic effects. By inhibiting cyclooxygenase types I and II, inhibits the synthesis of inflammatory mediators (prostaglandins, thromboxane, etc.). Stabilizes lysosomal membranes and inhibits the release of enzymes that contribute to tissue destruction during inflammation. Inhibits the activity of neutrophils. It has anti-bradykinin activity. The drug does not have antibacterial activity.

Pharmacokinetics

A single dose of 160 mg results in plasma levels of less than 400 ng/mL, insufficient for systemic action.

Indications

Symptomatic treatment of inflammatory diseases of the upper respiratory tract – tonsillitis (sore throat), laryngitis, pharyngitis;

inflammatory diseases of the oral cavity – stomatitis, gingivitis, glossitis, aphtha, periodontopathy, chronic periodontal disease;

as an analgesic during dental procedures.

Pharmacological effect

Pharmacotherapeutic group

Other drugs for the treatment of oral diseases.

ATX code: A01AD11.

Pharmacodynamics

Has anti-inflammatory, analgesic effect. By inhibiting cyclooxygenase types I and II, it inhibits the synthesis of inflammatory mediators (prostaglandins, thromboxane, etc.). Stabilizes lysosome membranes and delays the release of enzymes that contribute to tissue destruction during inflammation. Inhibits the activity of neutrophils. Has antibradykinin activity. The drug does not have an antibacterial effect.

Pharmacokinetics

A single dose of 160 mg results in a plasma drug level of less than 400 ng/ml, which is insufficient for systemic action.

Special instructions

Long-term use may cause hypersensitivity reactions. In this case, you should stop using the drug and select adequate treatment methods.

When using high doses and a long course of treatment, absorbed ketoprofen can compete with other drugs that have a high affinity for plasma proteins.

The drug contains methyl parahydroxybenzoate, which can cause allergic reactions (including delayed allergic reactions).

Impact on driving vehicles and machinery

There is no data on the negative effect of the drug on the ability to drive vehicles and engage in other potentially hazardous activities that require concentration and speed of psychomotor reactions.

Active ingredient

Ketoprofen

Composition

For 10 ml of solution:

Active ingredient:

ketoprofen lysine (ketoprofen lysine salt) 160.0 mg.

Excipients:

glycerol 85% 2000.0 mg,
ethanol 0.5 ml,
methyl parahydroxybenzoate 15.0 mg,
mint flavor 30.0 mg,
levomenthol 7.0 mg,
sodium saccharinate 20.0 mg,
dye “Verde Certosa” (brilliant green) 1.6 mg,
sodium hydrogen phosphate to pH 6.0-6.5,
purified water up to 10 ml.

Pregnancy

NSAIDs should not be used by women from the 20th week of pregnancy due to the possible development of oligohydramnios and/or kidney pathology in newborns (neonatal renal dysfunction). Use of the drug before the 20th week of pregnancy is possible only after consultation with a doctor, if the expected benefit to the mother outweighs the potential risk to the fetus.

The use of the drug during breastfeeding is not recommended.

Contraindications

Hypersensitivity to ketoprofen and other components of the drug, acetylsalicylic acid or other NSAIDs, complete or incomplete combination of bronchial asthma, recurrent nasal polyposis or paranasal sinuses and intolerance to acetylsalicylic acid and other NSAIDs (including a history), childhood (up to 12 years), pregnancy over 20 weeks.

With caution

Erosive and ulcerative lesions of the gastrointestinal tract (exacerbation), Crohn’s disease, diverticulitis, peptic ulcer, hemophilia and other bleeding disorders, chronic heart failure, bronchial asthma, old age, pregnancy (up to the 20th week).

Side Effects

Very rare cases of local irritation and angioedema (swelling of the lips, face, throat or tongue) have been reported, especially in patients with hypersensitivity to NSAIDs. There are no known cases of systemic side effects.

Interaction

Not detected.

Overdose

Currently, no cases of overdose with OCI have been reported.

Storage conditions

Store at a temperature not exceeding 25 oC.

Keep out of the reach of children!

Shelf life

Shelf life: 3 years.

Do not use the drug after the date indicated on the package.

Manufacturer

Dompe Pharmaceutici S.p.A., Italy