Oftarint, eye drops 10 ml

Pharmacotherapeutic group: Tissue repair stimulator.

ATX code: S01XA

Pharmacological properties

Pharmacodynamics

Complex drug that improves energy metabolism of the lens. Cytochrome C plays an important role in biochemical redox processes in the eyeball tissues and is an antioxidant. Adenosine is a precursor of adenosine triphosphate (ATP) and takes part in the metabolic processes of the lens. Nicotinamide stimulates the synthesis of nicotinamide dinucleotide (NAD), a cofactor of dehydrogenases.

Pharmacokinetics

When used topically, cytochrome C is not absorbed into the systemic bloodstream and is fully metabolized in the body. The breakdown of cytochrome C follows the same metabolic pathways as the breakdown of amino acids, and heme, which is broken down to bilirubin, is excreted in the bile.

Adenosine passes freely through the cornea. The half-life of adenosine from plasma is less than one minute, it is metabolized in almost all tissues to form inosine, xanthine and urate, which are freely excreted with the urine. Ribose, which is a constituent of adenosine, is metabolized to glyceraldehyde-3-phosphate, then to pyruvate and is burned in the Krebs cycle.

Nicotinamide is partially metabolized to nicotinic acid. Both of these compounds are methylated to N-methylnicotinamide, which is further broken down in the liver. Metabolites and unchanged nicotinamide are excreted in the urine.

Indications

Active ingredient

Composition

Composition of the drug per 1 ml:

The active ingredients:

Adenosine 2.0 mg

Nicotinamide 20.0 mg

Cytochrome C 0.675 mg

Excipients:

Sorbitol 10.0 mg

Sodium dihydrophosphate dihydrate 4.415 mg

Sodium hydrophosphate dihydrate 2.847 mg

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Sodium succinate hexahydrate 1.0 mg

Benzalkonium chloride 0.04 mg

Injection water up to 1 ml.

How to take, the dosage

Topically, 1-2 drops into the conjunctival sac 3 times a day.

The order of the vial:

After opening the bottle the drug may be used within 1 month. At the end of this period the product should be discarded.

The product should not be used if the vial is visibly damaged.

Special Instructions

Benzalkonium chloride, which is often used as a preservative in ophthalmic products, can cause keratopathy and/or toxic ulcerative keratopathy. Because it contains benzalkonium chloride, close monitoring is required for frequent or prolonged use in patients with dry eye syndrome or in cases of corneal damage. Benzalkonium chloride may discolor soft contact lenses. Soft contact lenses should be removed before application and put on again 15 minutes after dosing.

Patients who have transient eye irritation after injection should not drive a vehicle or operate machinery, machines, or any other equipment requiring good visual acuity immediately after using the eye drops.

Contraindications

Side effects

Ocular side effects: transient burning and tingling of the eyes, allergic conjunctivitis, contact dermatitis.

Systemic side effects are extremely rare. Short-term nausea, arterial hypotension, dizziness and shortness of breath may be observed. Nicotinic acid has a vasodilator effect and may cause a feeling of fever, fainting, and a throbbing sensation in the temples.

Pregnancy use

Similarities