Oftagel, eye gel 0.25% 10 g

Oftagel has a good moisturizing effect with prolonged contact with the cornea.

Pharmacodynamics

The polymeric chains of carboxyvinyl polymer (polyacrylate) interact with the mucin layer on the corneal epithelium. The non-ionized carboxylic acid residues in the polymer form hydrogen bonds with mucin molecules. Carbomer also contains more ionized sites that retain water around the molecule through electrostatic forces. In addition to bioadhesion, it increases tear viscosity by forming a protective moisturizing film on the corneal surface. It thickens the mucin and water layers of the tear film. In contact with epithelial cells it does not cause any specific effects.

Tolerability and safety have been studied in rabbits after a single injection and after use 4 times daily for 4 weeks. No drug-related reactions were observed in any study. Good tolerability of the drug both on the part of the tissues of the eye and the body as a whole was noted.

There was no evidence of teratogenic and mutagenic properties.

Pharmacokinetics

Because of the high molecular weight and cross-linkages in the structure of carbomer it is unlikely to penetrate and accumulate in the eyeball tissue. It is not absorbed into the blood from the lacrimal ducts and the gastrointestinal tract.

Indications

Diseases accompanied by dry eye syndrome, manifested by compensatory lacrimation, itching, burning, foreign body sensation in the eye:

Recuperative therapy after laser and corneal surgery.

Active ingredient

Composition

Active ingredient:

carbomer 974P 2.5 mg;

Supplements:

benzalkonium chloride;

sorbitol;

Lysine monohydrate;

How to take, the dosage

Conjunctival. 1 drop in the affected eye 1-4 times a day.

Interaction

Prolongs absorption of other eye medications.

If more than one type of eye drop is prescribed, they should be used at least 15 minutes apart, and Oftagel should always be the last one in.

Special Instructions

May cause a temporary decrease in visual acuity. Wait until visual acuity is fully restored before driving or operating mechanical devices.

Between injections, keep the bottle upside down to facilitate flow of the gel.

Hands should be washed before using the product.

Do not touch the eye or eyelid with the tip of the dropper. Close the bottle immediately after using the product.

Contraindications

Hypersensitivity to any component of the drug.

Side effects

Transient blurring of vision, a brief tingling sensation and local eye irritation may occur immediately after injection.

Pregnancy use

Pregnant and breastfeeding use is possible if the beneficial effect on the mother exceeds the risk to the fetus or the baby.

The use of the drug during pregnancy and lactation is possible only by prescription.

Similarities