Nystatin, vaginal suppositories 250000 units 10 pcs

Pharmacotherapeutic group

Antifungal agent

AtCode

G01AA

Pharmacodynamics:

The polyene antifungal antibiotic is highly active against yeast-like fungi of the genus Candida. In the structure of the antibiotic there are double bonds with high tropicity to the sterol structures of the cell membrane of fungi, which promotes incorporation of the drug molecule into the cell membrane and formation of a large number of channels through which uncontrolled transport of electrolytes occurs; increase of osmolarity inside the cell leads to its death. Resistance develops very slowly.

Pharmacokinetics: When used topically, the drug is practically not absorbed through the mucous membranes.

Indications

Treatment and prevention (with long-term local antimicrobial therapy) of candidiasis of the vaginal mucosa.

Pharmacological effect

Pharmacotherapeutic group

Antifungal agent

ATX code

G01AA

Pharmacodynamics:

A polyene antifungal antibiotic highly active against yeast-like fungi of the genus Candida. The structure of the antibiotic contains double bonds that are highly tropic to the sterol structures of the fungal cell membrane, which facilitates the incorporation of the drug molecule into the cell membrane and the formation of a large number of channels through which uncontrolled transport of electrolytes occurs; An increase in osmolarity inside the cell leads to its death. Resistance develops very slowly.

Pharmacokinetics:
When applied topically, it is practically not absorbed through the mucous membranes.

Special instructions

During menstruation, treatment should not be interrupted.

For fungal diseases of the vagina, simultaneous treatment of the sexual partner is recommended. During the treatment period, it is recommended to avoid sexual intercourse.

Impact on the ability to drive vehicles. Wed and fur.:
During the period of treatment with the drug, it is possible to drive vehicles and engage in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Active ingredient

Nystatin

Composition

Active ingredients:

nystatin – 55.5 mg (250,000 units)

Excipients:

propyl parahydroxybenzoate (nipazole) – 2.0 mg,

citric acid monohydrate – 0.075 mg,

Suppository base: solid fat – sufficient amount to obtain a suppository weighing 2.4 g

Pregnancy

The drug is contraindicated during pregnancy. Use during breastfeeding is possible since the drug is practically not absorbed through the mucous membranes and therefore does not penetrate into breast milk.

Contraindications

Hypersensitivity to the components of the drug; pregnancy; children under 18 years of age (there is no data on the effectiveness and safety of the use of nystatin in dosage form for intravaginal use in children).

Side Effects

Local hypersensitivity reactions are possible.

There is a possible risk of the spread of resistant forms of fungi, which requires discontinuation of the drug.

Interaction

With simultaneous use of nystatin with clotrimazole, the activity of the latter decreases.

Storage conditions

In a dry place, protected from light, at a temperature not exceeding 20 ° C. Keep out of the reach of children.

Shelf life

2 years. Do not use after the expiration date indicated on the package.

Manufacturer

Biosynthesis, Russia