Nurofen Express, gel 5% 100 g

Nurofen Express (ibuprofen) gel 5% is quickly absorbed, acting directly on the source of pain and has a double effect – analgesic and anti-inflammatory

The drug Nurofen Express in the form of gel for external use is easily applied and quickly absorbed into the skin.

Indications

As a local analgesic and anti-inflammatory agent for conditions such as muscle pain, back pain, arthritis, pain from ligament injuries and sprains, sports injuries and neuralgia.

Pharmacological effect

Nurofen Express (ibuprofen) gel 5% is quickly absorbed, acts directly on the source of pain and has a dual effect – analgesic and anti-inflammatory

The drug Nurofen Express in gel dosage form for external use is easily applied and quickly absorbed into the skin.

Special instructions

During long-term treatment, monitoring of the peripheral blood picture and the functional state of the liver and kidneys is necessary.

When symptoms of gastropathy appear, careful monitoring is indicated, including esophagogastroduodeposcopic examination, a complete blood count (hemoglobin determination), and a stool test for occult blood. P

If it is necessary to determine 17-ketosteroids, the drug should be discontinued 48 hours before the study.

Patients should refrain from all activities that require increased attention, rapid mental and motor reactions. During the treatment period you should refrain from drinking alcoholic beverages.

The doctor decides on the possibility of using Nurofen® for children individually in the following cases:

if the child receives other analgesics;
if there is a history of peptic ulcer disease, gastritis, ulcerative colitis, bleeding from the gastrointestinal tract;
for liver or kidney diseases;
when Helicobacter pylori is detected;
during therapy with indirect anticoagulants, drugs to lower blood pressure, corticosteroids, antiplatelet agents, diuretics, lithium drugs, methotrexate;
in children with bronchial asthma, urticaria.

Gel

After using the drug, wash your hands thoroughly.

Avoid getting the gel in your eyes and lips. Do not apply the gel to damaged areas of the skin, as well as to the area around the eyes and lips.

If the gel is accidentally ingested, gastrointestinal disorders may develop; in this situation, you should rinse your mouth and consult a doctor.

Active ingredient

Ibuprofen

Composition

1 g of gel for external use 5% contains:

Active ingredients:

Contraindications

– Hypersensitivity to ibuprofen or other components included in the drug.
– A history of hypersensitivity reactions (bronchial asthma, rhinitis, Quincke’s edema, urticaria) in response to the use of acetylsalicylic acid or other NSAIDs.
– Violations of the integrity of the skin at the site of application of the drug (including infected abrasions and wounds, weeping dermatitis, eczema).
– Children under 14 years of age. – Pregnancy III trimester.

Side Effects

The frequency of adverse reactions was assessed based on the following criteria: very common (≥ 1/10), common (from ≥ 1/100 to < 1/10), uncommon (from ≥ 1/1000 to < 1/100), rare (from ≥ 1/10000 to 1/10000), frequency unknown (frequency cannot be determined at based on available data).

The following adverse reactions were observed with short-term use of ibuprofen at a dose not exceeding 500 mg/day. When treating chronic conditions and with long-term use, other adverse reactions may occur.

– Immune system disorders

The frequency is unknown: hypersensitivity reactions – nonspecific allergic reactions and anaphylactic reactions, reactions from the respiratory tract (bronchial asthma, including its exacerbation, bronchospasm, shortness of breath, dyspnea), skin reactions (itching, urticaria, purpura, Quincke’s edema, exfoliative and bullous dermatoses, including toxic epidermal necrolysis syndrome Lyell), Stevens-Johnson syndrome, erythema multiforme).

– Gastrointestinal disorders

Frequency unknown: abdominal pain, dyspepsia.

– Renal and urinary tract disorders

Frequency unknown: renal dysfunction.

If side effects occur, you should immediately stop using the drug and consult a doctor.

Interaction

It is not recommended to take Nurofen tablets simultaneously with acetylsalicylic acid (ASA) and other NSAIDs.

When administered simultaneously, ibuprofen reduces the anti-inflammatory and antiplatelet effect of acetylsalicylic acid (ASA) (an increase in the incidence of acute coronary insufficiency in patients receiving small doses of acetylsalicylic acid (ASA) as an antiplatelet agent is possible after starting ibuprofen).

When prescribed with anticoagulant and thrombolytic drugs (alteplase, streptokinase, urotopase), the risk of bleeding simultaneously increases. Cefamandole, cefaperazone, cefotetan, valproic acid, plicamycin, increase the incidence of hypoprothrombinemia. Cyclosporine and gold preparations enhance the effect of ibuprofen on the synthesis of prostaglapdins in the kidneys, which is manifested by an increase in nephrotoxicity.

Ibuprofen increases the plasma concentration of cyclosporine and the likelihood of developing its hepatotoxic effects. Drugs that block tubular secretion reduce excretion and increase plasma concentrations of ibuprofen. Inducers of microsomal oxidation (phenytoin, ethanol, barbiturates, rifampicin, fepilbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites, increasing the risk of developing severe hepatotoxic reactions. Inhibitors of microsomal oxidation – reduce the risk of hepatotoxicity.

Reduces the hypotensive activity of vasodilators, natriuretic in furosemide and hydrochlorothiazide.

Reduces the effectiveness of uricosuric drugs, enhances the effect of indirect anticoagulants, aptiagregants, fibrinolytics. Increases the side effects of mineralocorticosteroids, glucocorticosteroids, estrogens, ethanol. Enhances the effect of oral hypoglycemic drugs, sulfonylurea derivatives and insulin.

Antacids and cholestyramine reduce absorption. Increases the blood concentration of digoxin, lithium preparations, methotrexate. Caffeine enhances the analgesic effect.

Drug interactions with Nurofen Gel have not been described to date. However, even when applied topically, ibuprofen can have a systemic effect, therefore, theoretically, the simultaneous use of the gel with other NSAIDs can lead to increased side effects.

Overdose

The likelihood of an accidental overdose of the drug in gel form is minimal.

In children, overdose symptoms may occur after ingestion of a dose exceeding 400 mg/kg body weight. In adults, the dose-dependent effect of overdose is less pronounced. The half-life of the drug in case of overdose is 1.5-3 hours.

If the drug is accidentally taken orally, the following symptoms may occur: headache, vomiting, decreased blood pressure.

Treatment: gastric lavage (only within an hour after administration), taking activated charcoal, alkaline drinking, forced diuresis, symptomatic therapy.

Storage conditions

At a temperature not higher than + 25°C, out of the reach of children.

Shelf life

3 years.

Manufacturer

Reckitt Benckiser Healthcare (UK) Limited, UK