Nurofen Express, gel 5% 100 g

How to take, the dosage

For external use only.

Read the instructions carefully before using this medicine.

Nurofen® Express Gel is indicated for adults and children over 14 years of age.

The first time you use the tube: after opening the lid, check that the safety foil on the neck of the tube is not damaged. Open the foil by pressing the outer side of the cap down.

Push 4-10 cc of the product (equivalent to about 50-125 mg of ibuprofen) from the tube onto your hand and gently massage the gel into the skin until it absorbs.

Wash your hands immediately after application.

Re-apply at least 4 hours afterwards. Do not use the gel more than four times within 24 hours. The maximum daily dose is 500 mg.

If symptoms persist or worsen after 2 weeks of use, you should stop treatment and see your doctor.

Do not exceed the stated dose.

Interaction

The simultaneous use of Nurofen tablets with acetylsalicylic acid (ASA) and other NSAIDs is not recommended.

Concomitant use of ibuprofen reduces the anti-inflammatory and antiplatelet effects of acetylsalicylic acid (ASA) (increased incidence of acute coronary failure in patients receiving low-dose acetylsalicylic acid (ASA) as an antiplatelet agent after starting ibuprofen).

When administered with anticoagulant and thrombolytic drugs (alteplase, streptokinase, urocipase) simultaneously the risk of bleeding increases. Cefamandole, cefaperazone, cefotetan, valproic acid, plikamycin, increase the purity of hypoprothrombinemia. Cyclosporine and gold drugs increase the effect of ibuprofen on the synthesis of prostaglandins in the kidneys, which is manifested by increased nephrotoxicity.

Ibuprofen increases the plasma concentration of cyclosporine and the likelihood of its hepatotoxic effects. Drugs that block tubular secretion reduce excretion and increase the plasma concentration of ibuprofen. Inducers of microsomal oxidation (phenytoin, ethanol, barbiturates, rifampicin, fepilbutazone, tricyclic aitylidepressants) increase the production of hydroxylated active metabolites, increasing the risk of severe hepatotoxic reactions. Microsomal oxidation inhibitors – reduce the risk of hepatotoxic effects.

Decreases the hypotensive activity of vasodilators, natriuretic activity of furosemide and hydrochlorthiazide.

Decreases the effectiveness of uricosuric drugs, increases the effect of indirect aithicoagulants, aptiaggregants, fibrinolytics. Increases the side effects of mineralocorticosteroids, glucocorticosteroids, estrogens, ethanol. Increases the effect of oral hypoglycemic drugs, sulfonylurea derivatives and insulin.

Antacids and colestyramine reduce absorption. Increases blood concentrations of digoxin, lithium drugs, methotrexate. Caffeine increases the analgesic effect.

Drug interactions of the drug Nurofen Gel have not been described so far. However, even with external use ibuprofen can have a systemic effect, and therefore theoretically the simultaneous use of the gel with other NSAIDs can increase the side effects.

Special Instructions

During long-term treatment it is necessary to monitor the peripheral blood picture and the functional state of the liver and kidneys.

In case of symptoms of gastropathy, close monitoring is indicated, including esophagogastroduodenoscopy, general blood count (hemoglobin determination), fecal occult blood test.

If it is necessary to determine 17-ketosteroids, the drug should be discontinued 48 hours before the study.

Patients should refrain from all activities requiring increased attention, rapid mental and motor reactions. During treatment, you should refrain from drinking alcohol.

The possibility of using Nurofen® for children is decided by the physician on an individual basis in the following cases:

• if the child is receiving other analgesic agents;
• If there is a history of peptic ulcer, gastritis, ulcerative colitis, gastrointestinal bleeding;
• in case of liver or kidney disease;
• in the presence of Helicobacter pylori;
• on the background of therapy with indirect anticoagulants, blood pressure lowering drugs, GCS, antiaggregants, diuretics, lithium, methotrexate;
• in children with bronchial asthma, urticaria.

Gel

Wash hands thoroughly after using the product.

You should avoid getting the gel in your eyes and on your lips. Do not apply to any damaged areas of skin or to the eye or lip area.

Inadvertent ingestion may cause gastrointestinal disorders; if this happens, rinse out your mouth and see a doctor.

Contraindications

– Hypersensitivity to ibuprofen or other components of the drug.
– History of hypersensitivity reactions (bronchial asthma, rhinitis, Quincke’s edema, urticaria) in response to use of acetylsalicylic acid or other NSAIDs.