Nurofen Express, 200 mg capsules 8 pcs

Name: Nurofen Express, 200 mg capsules 8 pcs
SKU: 251844
Availability: InStock

€4.00

EAN: 5000158106116 SKU: 251844 Categories: Medicine, Pain and fever, Painkillers

Description

The mechanism of action of ibuprofen, a propionic acid derivative of the group of non-steroidal anti-inflammatory drugs (NSAIDs), is due to the inhibition of the synthesis of prostaglandins mediators of pain, inflammation and hyperthermia. Indiscriminately blocks cyclooxygenase 1 (COX-1) and cyclooxygenase 2 (COX-2), thereby inhibiting the synthesis of prostaglandins. It has a fast directed action against pain (analgesic), antipyretic and anti-inflammatory effect. In addition, ibuprofen reversibly inhibits platelet aggregation.

Pharmacokinetics

Absorption is high, quickly and almost completely absorbed from the gastrointestinal tract (GIT). After taking 2 capsules on an empty stomach ibuprofen is detected in plasma after 10 minutes, maximum concentration (Cmax) of ibuprofen in plasma is reached after 30-40 minutes, twice as fast as after taking the equivalent dose of the drug Nurofen in dosage form of 200 mg coated tablets.

Taking the drug with food may increase time to reach maximum concentration (TSmax). The binding to plasma proteins is more than 90%, the half-life (T1/2) is 2 hours. Slowly penetrates into the joint cavity, stays in synovial fluid, creating higher concentrations in it than in blood plasma. After absorption, about 60% of the pharmacologically inactive R-form is slowly transformed into the active S-form. It is metabolized in the liver. It is excreted by the kidneys (not more than 1% unchanged) and, to a lesser extent, with the bile.

In elderly people no significant differences in the pharmacokinetic profile of the drug were found compared to younger people.

In limited studies ibuprofen was detected in breast milk at very low concentrations.

Indications
Indications
NurofenÂ® Express is used for headache, migraine, toothache, painful menstruation, neuralgia, back pain, muscle and rheumatic pain; febrile states at flu and colds.

Active ingredient
Active ingredient

How to take, the dosage
How to take, the dosage

Interaction
Interaction
Combined use of ibuprofen with the following drugs should be avoided:
Cautiously use with the following medicines:

Special Instructions
Special Instructions
Influence on driving and operating machinery
Patients who experience dizziness, drowsiness, lethargy or visual disturbances while taking ibuprofen should avoid driving or operating machinery.

Synopsis
Synopsis

Contraindications
Contraindications

Side effects
Side effects

Overdose
Overdose
In children, overdose symptoms may occur after a dose greater than 400 mg/kg body weight. In adults, the dose-dependent effect of overdose is less pronounced. The half-life of the drug in overdose is 1.5-3 hours.
Symptoms: nausea, vomiting, epigastric pain or, less frequently, diarrhea, tinnitus, headache and gastrointestinal bleeding. In more severe cases, manifestations of the central nervous system are observed: drowsiness, rarely – agitation, convulsions, disorientation, coma. In cases of severe poisoning metabolic acidosis and increased prothrombin time, renal failure, liver tissue damage, decreased blood pressure, respiratory depression and cyanosis may develop. In patients with bronchial asthma, exacerbation of this disease is possible.
The treatment: symptomatic, with mandatory provision of airway patency, ECG monitoring and basic vital signs until the patient’s condition normalizes.
The oral administration of activated charcoal or gastric lavage within 1 hour after taking a potentially toxic dose of ibuprofen is recommended. If ibuprofen has already been absorbed, alkaline drinking may be prescribed in order to eliminate the acidic derivative of ibuprofen by the kidneys, forced diuresis. Frequent or prolonged seizures should be controlled with intravenous diazepam or lorazepam. In worsening bronchial asthma the use of bronchodilators is recommended.
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Similarities
Similarities

Additional information
Weight 0.015 kg
Shelf life
2 years
Conditions of storage
Store in a dry place at a temperature not exceeding 25 ° C.
Manufacturer
Reckitt Benckiser Healthcare International Ltd, United Kingdom
Medication form
capsules
Brand
Reckitt Benckiser Healthcare International Ltd