Nurofen, 200 mg 10 pcs

The mechanism of action of ibuprofen, a derivative of propionic acid from the group of non-steroidal anti-inflammatory drugs (NSAIDs), is due to inhibition of prostaglandin synthesis mediators of pain, inflammation and hyperthermia.

Indiscriminately blocks cyclooxygenase 1 (COX-1) and cyclooxygenase 2 (COX-2), thereby inhibiting prostaglandin synthesis. It has a fast directed action against pain (analgesic), antipyretic and anti-inflammatory effect. In addition, ibuprofen reversibly inhibits platelet aggregation. The analgesic effect of the drug lasts up to 8 hours.

Pharmacokinetics

Absorption is high, quickly and almost completely absorbed from the gastrointestinal tract (GIT). After taking the drug on an empty stomach the maximum concentration (Cmax) of ibuprofen in blood plasma is reached after 45 minutes. If the drug is taken with food it may increase the time to reach the maximum concentration (Òcmax) up to 1-2 hours.

Binding with blood plasma proteins is 90%. Slowly penetrates into the joint cavity, stays in synovial fluid, creating higher concentrations in it than in blood plasma. Lower concentrations of ibuprofen are found in cerebrospinal fluid compared to blood plasma. After absorption about 60% of pharmacologically inactive R-form is slowly transformed into active S-form. It is metabolized in the liver. The half-life (T1/2) is 2 hours. It is excreted by the kidneys (not more than 1% unchanged) and, to a lesser extent, with bile.

In limited studies ibuprofen was detected in breast milk in very low concentrations.

Indications

Active ingredient

Composition

Active substance:

Ibuprofen – 200 mg.

Associates:

croscarmellose sodium – 30 mg,

sodium lauryl sulfate – 0.5 mg,

sodium citrate dihydrate – 43.5 mg,

stearic acid – 2 mg,

silicon dioxide colloid – 1 mg.

The shell composition:

Sodium carmellose – 0.7 mg, talc – 33 mg, acacia gum – 0.6 mg, sucrose – 116.1 mg, titanium dioxide – 1.4 mg, macrogol 6000 – 0.2 mg, black ink (Opacode S-1-277001) (shellac – 28.225%, iron oxide black dye (E172) – 24.65%, propylene glycol – 1.3%, isopropanol* – 0.55%, butanol* – 9.75%, ethanol* – 32.275%, purified water* – 3.25%).

How to take, the dosage

Interaction

The simultaneous use of Nurofen tablets with acetylsalicylic acid (ASA) and other NSAIDs is not recommended.

Concomitant use of ibuprofen reduces the anti-inflammatory and antiplatelet effects of acetylsalicylic acid (ASA) (increased incidence of acute coronary failure in patients receiving low-dose acetylsalicylic acid (ASA) as an antiplatelet agent after starting ibuprofen).

When administered with anticoagulant and thrombolytic drugs (alteplase, streptokinase, urocipase) simultaneously the risk of bleeding increases. Cefamandole, cefaperazone, cefotetan, valproic acid, plikamycin, increase the purity of hypoprothrombinemia. Cyclosporine and gold drugs increase the effect of ibuprofen on the synthesis of prostaglandins in the kidneys, which is manifested by increased nephrotoxicity.

Ibuprofen increases the plasma concentration of cyclosporine and the likelihood of its hepatotoxic effects. Drugs that block tubular secretion reduce excretion and increase the plasma concentration of ibuprofen. Inducers of microsomal oxidation (phenytoin, ethanol, barbiturates, rifampicin, fepilbutazone, tricyclic aitylidepressants) increase the production of hydroxylated active metabolites, increasing the risk of severe hepatotoxic reactions. Microsomal oxidation inhibitors – reduce the risk of hepatotoxic effects.

Decreases the hypotensive activity of vasodilators, natriuretic activity of furosemide and hydrochlorthiazide.

Decreases the effectiveness of uricosuric drugs, increases the effect of indirect aithicoagulants, aptiaggregants, fibrinolytics. Increases the side effects of mineralocorticosteroids, glucocorticosteroids, estrogens, ethanol. Increases the effect of oral hypoglycemic drugs, sulfonylurea derivatives and insulin.

Antacids and colestyramine reduce absorption. Increases the blood concentration of digoxin, lithium drugs, methotrexate. Caffeine increases the analgesic effect.

Synopsis

Contraindications

Side effects

Overdose

Symptoms: abdominal pain, nausea, vomiting, lethargy, drowsiness, depression, headache, tinnitus, metabolic acidosis, coma, acute renal failure, decreased blood pressure (BP), bradycardia, tachycardia, atrial fibrillation, respiratory arrest.

Treatment: gastric lavage (only within 1 hour after ingestion), activated charcoal, alkaline drinking, forced diuresis, symptomatic therapy.

Similarities