Nitroxoline, 50 mg 50 pcs.

An antimicrobial agent derived from 8-oxyquinoline. The mechanism of action is associated with selective inhibition of bacterial DNA synthesis.

Nitroxoline is active against Gram-positive bacteria: Staphylococcus spp. (including Staphylococcus aureus), Streptococcus spp. beta-haemolytic streptococci, Streptococcus pneumoniae, Enterococcus faecalis), Corynebacterium diphtheriae, Bacillus subtilis; Gram-negative bacteria: Neisseria gonorrhoeae, Escherichia coli, Proteus spp, Klebsiella spp., Salmonella spp., Shigella spp., Enterobacter spp.

Nitroxoline is also active against Mycobacterium tuberculosis, Trichomonas vaginalis, some types of fungi (Candida spp., dermatophytes, molds, some deep mycosis agents).

Indications

• Infectious inflammatory diseases of the urinary tract caused by susceptible microorganisms (including pyelonephritis, cystitis, urethritis), epididymitis;
• infected adenoma or carcinoma of the prostate and others.
• prevention of infectious complications at diagnostic and therapeutic interventions (catheterization, cystoscopy, after operations on the kidneys and urinary tracts).
  

Active ingredient

Nitroxoline

Composition

Active ingredient:

nitroxoline 50 mg;

Ancillary substances:

Potato starch,

lactose monohydrate,

calcium stearate,

talc,

aerosil,

sugar,

magnesium carbonate,

povidone,

titanium dioxide,

tartrazine,

Ponceau 4 R,

beeswax,

vaseline oil

How to take, the dosage

Nitroxoline is taken orally with or after meals. The daily dose for adults is 400 mg (100 mg four times a day). In severe cases, the daily dose can be increased to 600 to 800 mg. The highest daily dose for adults is 800 mg. The course of treatment is 2 to 3 weeks. An average daily dose of Nitroxolin for children from 3 to 5 years is 200 mg, for children over 5 years – 200-400 mg. The daily dose is divided into 4 doses. The duration of the course of treatment is 2 to 3 weeks.

In chronic urinary tract infections Nitroxolin may be prescribed in repeated courses of 2 weeks with a 2-week break. For prophylaxis of infections after kidney and urinary tract operations Nitroxolin is prescribed 100 mg per dose 4 times a day for 2 to 3 weeks.

Interaction

When combining Nitroxolin with drugs of tetracycline group, summation of the effects of each drug is observed, with nystatin and levorin – potentiation of action.

In order to avoid summation of the negative neurotropic effect, Nitroxoline should not be combined with nitrofurans.

Special Instructions

The urine is stained saffron yellow during treatment.

Contraindications

Hypersensitivity (including to other 8-oxyquinoline derivatives), renal dysfunction accompanied by oliguria, anuria; severe liver disease, cataract, neuritis, polyneuritis, glucose-6-phosphate dehydrogenase deficiency, pregnancy, lactation.

Side effects

Dyspepsia (nausea, vomiting), loss of appetite, allergic reactions (skin rash); tachycardia, ataxia, headache, paresthesias, polyneuropathy, liver function disorders.