Nimulide, 100 mg 10 pcs

Nimulide is a non-narcotic anti-inflammatory drug (NSAID) of sulfonanilide class, a selective COX-2 inhibitor. It has anti-inflammatory, analgesic, antipyretic effects.

Nimesulide belongs to NSAIDs, the mechanism of action of which is connected with selective inhibition of COX-2 and influence on several other factors – inhibition of platelet-activating factor, tumor necrosis factor-alpha, inhibition of proteinases and histamine.

With selective inhibition of COX-2 it decreases biosynthesis of PG in inflammation focus, has less pronounced inhibitory effect on COX-1 (causes side effects connected with inhibition of PG synthesis in healthy tissues less frequently).

.

Indications

The drug is intended for symptomatic therapy, reducing pain and inflammation at the time of use, does not affect the progression of the disease.

Active ingredient

Composition

Active ingredient:

Nimesulide 100 mg;

Supplements:

mannitol; aspartame;

sodium carboxymethyl starch;

sodium methyl parahydroxybenzoate;

sodium propyl parahydroxybenzoate;

potassium sorbate;

sodium croscarmellose;

silicon dioxide colloid;

magnesium stearate;

orange flavoring;

purified water

How to take, the dosage

Lingual tablet should be placed on the tongue, where it immediately begins to dissolve, then swallow the saliva in which the tablet dissolved.

The maximum daily dose is 200 mg.

Interaction

The effect of drugs that reduce blood clotting is increased when they are used simultaneously with nimesulide.

Nimesulide may reduce the effect of furosemide. Reduces the therapeutic effect of antihypertensive drugs. Nimesulide increases the onset of side effects when concomitant administration of methotrexate.

Plasma lithium levels are increased when concomitant administration of lithium and nimesulide.

Nimesulide may increase the nephrotoxic effect of cyclosporine on the kidneys.

The use with glucocorticosteroids, serotonin reuptake inhibitors increases the risk of GI bleeding.

Special Instructions

Nimulide should be used with caution in patients who are prone to bleeding, patients with upper gastrointestinal disorders or patients receiving anticoagulants.

Because Nimulide is partially excreted by the kidneys, its dosage should be reduced for patients with impaired renal function, depending on creatinine clearance values.
Given reports of visual disturbances in patients taking other NSAIDs, treatment should be stopped immediately if any visual disturbance appears, and the patient should be examined by an eye doctor.
P

The drug may cause fluid retention in the tissues, so patients with high blood pressure and with cardiac abnormalities should use Nimulide with extreme caution.

To reduce the risk of gastrointestinal adverse events, the lowest effective dose should be used for the shortest possible course.
Influence on driving and operating machinery

Patients who have pronounced side effects: dizziness, somnolence, blurred vision should be careful when driving motor transport and engaging in other potentially dangerous activities requiring increased concentration and quick psychomotor reactions.

Contraindications

Side effects

Systemic reactions: Heartburn, nausea, vomiting, diarrhea, gastralgia, gastrointestinal mucosal ulceration, headache, dizziness, fluid retention, drowsiness, itching, urticaria, bronchospasm, allergic reactions (skin rash, anaphylactic shock), thrombocytopenia, leukopenia, anemia, agranulocytosis, increased liver transaminase activity, prolonged bleeding time, hematuria.

Local reactions (gel): skin irritation, skin rash, peeling, skin itching, transient change in skin color (not requiring withdrawal of the drug).

Overdose

Symptoms: apathy, drowsiness, nausea, vomiting. Gastrointestinal bleeding, arterial hypertension, acute renal failure, respiratory depression may occur.

Treatment: symptomatic treatment of the patient is required, there is no specific antidote. If overdose occurred within the last 4 hours it is necessary to induce vomiting, provide intake of activated charcoal (60-100 g per adult), osmotic laxatives. Forced diuresis and hemodialysis are ineffective due to high protein binding of the drug.

Pregnancy use

It is contraindicated during pregnancy and lactation.

Similarities