Nimica, 100 mg 20 pcs.

Nymica is a non-steroidal anti-inflammatory drug (NSAID) of the sulfonanilide class. It has anti-inflammatory, analgesic and antipyretic effects.

Nimisulide belongs to new generation of NSAIDs, the mechanism of action of which is connected with selective inhibition of cyclooxygenase II and influence on several other factors: inhibition of platelet-activating factor, tumor necrosis factor alpha, inhibition of proteinases and histamine.

Pharmacokinetics

In oral administration, it is well absorbed from the gastrointestinal tract. The maximum concentration of the active substance in plasma is reached 1.5-2.5 hours after taking the drug.

The use of the drug concomitantly with food reduces the absorption rate, but does not affect its degree. Binding to plasma proteins is 99%, the volume of distribution is 0.19-0.35 l/kg. Nimesulide is actively metabolized in the liver with the formation of several metabolites, excreted mainly in the urine (70%) and feces (30%).

In patients with renal insufficiency (creatinine clearance 30-80 ml/min) and in children and elderly patients pharmacokinetic profile of nimesulide did not change significantly.

Indications

arthritis
pain of various origins (dental and menstrual pain, injuries)
high temperature.

Pharmacological effect

Nimica is a non-steroidal anti-inflammatory drug (NSAID) from the sulfonanilide class. It has anti-inflammatory, analgesic and antipyretic effects.

Nimisulide belongs to a new generation of NSAIDs, the mechanism of action of which is associated with selective inhibition of cyclooxygenase II and effects on a number of other factors: suppression of platelet activating factor, tumor necrosis factor alpha, suppression of proteinases and histamine.

Pharmacokinetics

When taken orally, it is well absorbed from the gastrointestinal tract. The maximum concentration of the active substance in the blood plasma is achieved 1.5–2.5 hours after taking the drug.

Using the drug simultaneously with food reduces the rate of absorption, but without affecting its degree. Plasma protein binding is 99%, volume of distribution is 0.19–0.35 l/kg. Nimesulide is actively metabolized in the liver with the formation of several metabolites, excreted mainly in urine (70%) and feces (30%).

In patients with renal failure (creatinine clearance 30–80 ml/min), as well as in children and the elderly, the pharmacokinetic profile of nimesulide did not change significantly.

Special instructions

Use with caution simultaneously with diuretics, blood pressure medications, and other painkillers, anti-inflammatory, and antidiabetic drugs.

Active ingredient

Nimesulide

Composition

1 tablet contains:

Active ingredients:

nimesulide – 100 mg

Excipients:

starch,

microcrystalline cellulose,

colloidal silicon dioxide,

gelatinized starch,

citric acid monohydrate,

purified talc,

sodium starch glycolate,

aspartame,

fruit flavor (for 100 mg tablets) magnesium stearate,

purified water.

Pregnancy

Nimica is contraindicated during pregnancy and breastfeeding.

Contraindications

severe renal dysfunction
erosive and ulcerative lesions of the stomach
hypersensitivity to the drug Nimika.

Side Effects

From the nervous system and sensory organs: rarely – headache, dizziness, drowsiness.

From the cardiovascular system and blood (hematopoiesis, hemostasis): very rarely – thrombocytopenia.

From the gastrointestinal tract: rarely – nausea, heartburn, stomach pain, tarry stools, melena.

From the skin: rarely – petechiae, purpura.

From the genitourinary system: rarely – oliguria.

Allergic reactions: exanthema, erythema, urticaria.

Interaction

Caution should be exercised when using Nimesulide simultaneously with:

digoxin, phenytoin, and lithium preparations;
diuretics and antihypertensive drugs;
other NSAIDs;
anticoagulants;
cyclosporine;
methotrexate;
oral antidiabetic agents.

because at the level of binding to plasma proteins, Nimesulide increases the concentration of drugs that compete for binding to the protein.

Storage conditions

In a dry place, protected from light, at a temperature not exceeding 25 °C

Shelf life

2 years

Manufacturer

Ipka Laboratories Limited, India