Nifuroxazide, 200 mg capsules 14 pcs

Pharmacotherapeutic group: Antimicrobial agent – nitrofuran

ATC code: A07AX03

Pharmacodynamics:

Nifuroxazide is an antimicrobial agent derived from nitrofuran. It blocks activity of dehydrogenases and inhibits respiratory chain tricarboxylic acid cycle and several other biochemical processes in microbial cell. It destroys the membrane of the microbial cell and decreases production of toxins by microorganisms.

Highly active against Campylobacter jejuni Escherichia coli Salmonella spp Shigella spp; Clostridium perfringens Vibrio cholerae pathogenic Vibrions and Vibrio parahaemolytique Staphylococcus spp.

Low sensitivity to nifuroxazide: Citrobacter spp Enterobacter cloacae and Proteus indologenes.

Resistant to nifuroxazide: Klebsiella spp Proteus mirabilis Providencia spp. Pseudomonas spp.

Nifuroxazide does not disturb the balance of intestinal microflora. In acute bacterial diarrhea it restores intestinal eubiosis. In case of infection with enterotropic viruses it prevents development of bacterial superinfection.

Pharmacokinetics:

Nifuroxazide is practically not absorbed from digestive tract after oral administration and its antibacterial effect is produced only in intestinal lumen. Nifuroxazide is excreted by the intestine: 20% in unchanged form and the remaining amount of nifuroxazide – chemically changed.

Indications

Active ingredient

Composition

1 capsule 200 mg:

Active ingredient: nifuroxazid – 200.00 mg.

Excipients: sucrose – 70.00 mg; microcrystalline cellulose – 41.50 mg; corn starch – 35.00 mg; magnesium stearate – 3.50 mg.

Capsule contents: quinoline yellow dye – 0.7500%; sunset yellow dye – 0.0059%; titanium dioxide – 2.0000%; gelatin – up to 100%. Capsule cap composition: quinoline yellow dye – 0.7500%; sunset yellow dye – 0.0059%; titanium dioxide – 2.0000%; gelatin – up to 100%.

How to take, the dosage

It is taken orally. The capsule should be swallowed whole with a small amount of water.

In children from 3 to 6 years of age: 200 mg (1 capsule) 3 times daily (8 hours between doses) a daily dose of 600 mg.

Children from 6 to 18 years: 200 mg (1 capsule) 3 to 4 times daily (6 to 8 hours between doses) a daily dose of 600-800 mg.

Adults: 200 mg (1 capsule) 4 times daily (6-hour interval between doses) daily dose is 800 mg.

The course of treatment lasts 5-7 days but not more than 7 days. If there is no improvement after the first 3 days, see a physician. Only use the drug according to the route of administration and in the dosage indicated in the instructions. If necessary, please consult a physician before using this medicine.

Interaction

Concomitant use with drugs causing disulfiram-like reactions with drugs depressing the function of the central nervous system is not recommended.

If you are taking other medicines (including over-the-counter ones), consult your physician before using Nifuroxazid.

Special Instructions

In the treatment of diarrhea, rehydration therapy should be given concomitantly with nifuroxazide therapy.

In case of bacterial diarrhea with signs of systemic damage (worsening of general condition, increase in body temperature, symptoms of intoxication or infection), a physician should be consulted to decide on the use of antibacterial drugs of systemic action.

In case of symptoms of hypersensitivity (dyspnea, rash, itching) the drug should be discontinued.

Alcohol consumption is prohibited during therapy.

The maximum daily dose of the drug (800 mg) contains 0023 CPUs.

The drug has no effect on the ability to operate vehicles and machinery.

Contraindications

– fructose intolerance, glucose-galactose malabsorption syndrome or insufficiency of sucrose and isomaltase;

– pregnancy;

– childhood under 3 years.

Side effects

Overdose

Pregnancy use

There have been no teratogenic effects detected in animal studies. However, as a precautionary measure, it is not recommended to take nifuroxazide during pregnancy.

During the lactation period it is possible to continue breastfeeding in case of a short course of treatment with the drug. It is necessary to consult a physician.

Similarities