Nifural, 200 mg capsules 16 pcs

Pharmacotherapeutic group:

Antimicrobial agent-nitrofuran.

ATX code: A07AX03.

Pharmacological action

Pharmacodynamics

Nifuroxazide is an intestinal antiseptic, a 5-nitrofuran derivative, highly active against Campylobacter jejuni, Escherichia coli, Salmonella spp, Shigella spp; Clostridium perfingens, Vibrio cholerae, pathogenic Vibrions and Vibrio parahaemolytique, Staphylococcus spp. Weakly sensitive to nifuroxazide: Citrobacter spp, Enterobacter cloacae and Proteus indologenes. Resistant to Nifuroxazide: Klebsiella spp, Proteus mirabilis, Providencia spp, Pseudomonas spp.

Nifuroxazide presumably inhibits dehydrogenase activity and protein synthesis in bacterial cells. It does not cause the emergence of drug-resistant strains, also cross-resistance with other antibacterial drugs was not observed. The effectiveness of nifuroxazide does not depend on the pH in the intestinal lumen or on the sensitivity of microorganisms to antibacterial drugs. It does not affect the composition of normal bacterial flora of the digestive tract.

In acute bacterial diarrhea it restores intestinal eubiosis. In infection with enterotropic viruses prevents the development of bacterial superinfection.

Pharmacokinetics

Nifuroxazide is practically not absorbed from the digestive tract after oral administration and its antibacterial effect is exclusively in the intestinal lumen. Nifuroxazide is excreted by the intestine: 20% unchanged and the rest chemically altered nifuroxazide.