Nifural, 200 mg capsules 16 pcs

Indications

Acute bacterial diarrhea, occurring without deterioration in general condition, increase in body temperature, or intoxication.

Pharmacological effect

Pharmacotherapeutic group:

antimicrobial agent – nitrofuran.

ATX code: A07AX03.

Pharmacological action

Pharmacodynamics

Nifuroxazide is an intestinal antiseptic, a derivative of 5-nitrofuran, highly active against Campylobacter jejuni, Escherichia coli, Salmonella spp, Shigella spp; Clostridium perfingens, Vibrio cholerae, pathogenic Vibrions and Vibrio parahaemolytique, Staphylococcus spp. Weakly sensitive to nifuroxazide: Citrobacter spp, Enterobacter cloacae and Proteus indologenes. Resistant to nifuroxazide: Klebsiella spp, Proteus mirabilis, Providencia spp, Pseudomonas spp.

Nifuroxazide presumably inhibits the activity of dehydrogenases and protein synthesis in bacterial cells. It does not cause the emergence of drug-resistant strains, and cross-resistance with other antibacterial drugs has not been observed. The effectiveness of nifuroxazide does not depend either on the pH existing in the intestinal lumen or on the sensitivity of microorganisms to antibacterial drugs. Does not affect the composition of the normal bacterial flora of the digestive tract.

In acute bacterial diarrhea, it restores intestinal eubiosis. When infected with enterotropic viruses, it prevents the development of bacterial superinfection.

Pharmacokinetics

After oral administration, nifuroxazide is practically not absorbed from the digestive tract and exerts its antibacterial effect exclusively in the intestinal lumen. Nifuroxazide is excreted by the intestines: 20% unchanged, and the remaining amount of nifuroxazide is chemically modified.

Active ingredient

Nifuroxazide

Composition

1 capsule contains:

active ingredient:

nifuroxazide 100/200 mg;

excipients:

sugar (sucrose),

category “extra”

corn starch,

microcrystalline cellulose,

magnesium stearate;

hard gelatin capsule:

body and cap of the capsule – titanium dioxide,

iron oxide yellow,

gelatin.

Contraindications

Hypersensitivity to nifuroxazide, nitrofuran derivatives or any excipients of the drug, sucrase/isomaltase deficiency, fructose intolerance, glucose-galactose malabsorption, pregnancy, children under 3 years of age.

Manufacturer

Alium JSC, Russia