Neurobion, 3 ml 3 pcs.

Indications

Composition

How to take, the dosage

Interaction

When used concomitantly with levodopa, pyridoxine may decrease the antiparkinsonian effect of levodopa.

The concomitant use of pyridoxine antagonists (e.g. isoniazid, hydralazine, penicillamine or cycloserine) may increase the need for pyridoxine.

Thiamine is inactivated by fluorouracil. Fluorouracil competitively inhibits the phosphorylation of thiamine to thiamine pyrophosphate.

Antacids reduce thiamine absorption.

Petal diuretics such as furosemide may block tubular resorption, thereby increasing thiamine excretion with prolonged use, resulting in lower blood thiamine levels.

Ingestion of alcohol and black tea leads to decreased thiamine absorption.

Drinks containing sulfites (such as wine) increase the degradation of thiamine.

Special Instructions

Contraindications

Overdose

Vitamin B1. Thiamine has a wide therapeutic range. Very high doses (>10 g) have a ganglioblocking effect and inhibit nerve impulse transmission, i.e. have a myorelaxant effect.

Vitamin B6. Pyridoxine has very little toxicity. Use of pyridoxine for 2 months or more at a dose greater than 1 g per day may cause neurotoxic effects.

In case of overdose after oral administration of more than 2 g per day the following effects were observed – neuropathies with ataxia, impaired sensitivity, cerebral convulsions with ECG changes, as well as, in some cases, hypochromic anemia and seborrheic dermatitis.

Vitamin B12. Eczematous skin changes and a benign form of acne have been observed after parenteral administration of a high dose (and in rare cases after oral administration).

Treatment: therapeutic measures in case of overdose are gastrointestinal lavage, activated charcoal intake, prescription of symptomatic therapy.