Naftifin, cream 1% 15 g

Pharmacodynamics

Naftifin is an antifungal agent for external use, belonging to the class of allilamines. The mechanism of action is associated with inhibition of squalene-2,3-epoxidase, which leads to reduction of formation of ergosterol which is a part of the cell wall of the fungus.

It is active against dermatophytes such as Trichophyton, Epidermophyton, Microsporum, molds {Aspergillus spp.), yeast fungi {Candida spp., Pityrosporum) and other fungi (such as Sporothrix schenckii). Against dermatophytes and aspergillus naphthifin acts fungicidal.

In yeast fungi the drug has fungicidal or fungistatic activity depending on the strain of the microorganism. It has antibacterial activity against Gram-positive and Gram-negative microorganisms which may cause secondary bacterial infections. It has anti-inflammatory action, which contributes to the rapid disappearance of symptoms of inflammation, especially itching.

Pharmacokinetics

When applied externally, it penetrates the skin well, creating sustained antifungal concentrations in its various layers. After application on the skin less than 6% of naphthifin is absorbed systemically. Absorbed amount is partially metabolized and excreted by kidneys and intestine. Half-life of naphthifin is 2-3 days.

Indications

• Fungal infections of the skin and skin folds (tinea corporis, tinea inquinalis);
• finger mycoses (tinea manum, tinea pedum);
• fungal nail infections (onychomycosis);
• dermatomycoses (with or without associated itching).

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Active ingredient

Naftifin

Composition

The active ingredient:

Naphthyphine hydrochloride-10 mg.

Auxiliary substances:

Sodium hydroxide-1.2 mg,

Benzyl alcohol-10.0 mg,

sorbitan stearate – 19.0 mg,

cetyl palmitate – 20.0 mg,

cetyl alcohol – 40.0 mg,

stearic alcohol – 40.0 mg,

polysorbate 60-61.0 mg,

isopropyl myristate – 80.0 mg,

purified water – up to 1000 mg.

How to take, the dosage

Externally.

In case of skin lesions

The drug Naftifin is applied once a day on the affected skin surface and adjacent areas (approximately 1 cm of healthy skin at the edges of the affected area) after they have been thoroughly cleaned and dried.

The duration of therapy for dermatitis and goats is 2-4 weeks (up to 8 weeks if necessary); for candidiasis it is 4 weeks.

In case of nail lesions

The drug Naphtifine is applied 2 times a day on the affected nail. Before the first use, the affected part of the nail is removed as much as possible with scissors or a nail file.

The duration of therapy for onychomycosis is up to 6 months.

To prevent recurrence, treatment should be continued for at least 2 weeks after clinical symptoms have disappeared.

If there is no improvement after treatment or if new symptoms develop, you should consult a physician. Use the drug only according to the route of administration and in the dosage indicated in the instructions. If necessary, please talk to your doctor before using the medicine.

Interaction

Interaction with other drugs has not been studied.

Special Instructions

Naftifine is not intended for use in ophthalmology. The drug should not be allowed to get into the eyes.

Course treatment is required to achieve a therapeutic effect.

The effect of the drug on the ability to drive vehicles, machinery

The drug naphthifine has no adverse effect on the ability to drive vehicles and perform other activities requiring concentration and quick psychomotor reactions.

Contraindications

High sensitivity to naphthyphine, benzyl alcohol or other components of the drug. Pregnancy and breastfeeding (safety and effectiveness of use have not been established).

Cautions

• Childhood (clinical experience limited).
• Pregnancy and breastfeeding
• Pregnancy and breastfeeding are contraindicated (the safety and effectiveness of naphthifin in this patient population has not been studied).
  

Side effects

In some cases there may be local reactions: dry skin, skin hyperemia (redness) and burning. The side effects are reversible and do not require withdrawal of treatment. If any of the side effects mentioned in the instructions are aggravated, or any other side effects not mentioned in the instructions are noted, you should inform your doctor immediately.

Overdose

When using the drug in accordance with the instructions for use, overdose is unlikely. In case of accidental ingestion gastric lavage and symptomatic therapy are indicated.

Similarities

Exoderil, Mycoderil, Mizol, Naftoderil, Naftifin, Fungoderil