Pharmacodynamics
Naftifin is an antifungal agent for external use, belonging to the class of allilamines. The mechanism of action is associated with inhibition of squalene-2,3-epoxidase, which leads to reduction of formation of ergosterol which is a part of the cell wall of the fungus.
It is active against dermatophytes such as Trichophyton, Epidermophyton, Microsporum, molds {Aspergillus spp.), yeast fungi {Candida spp., Pityrosporum) and other fungi (such as Sporothrix schenckii). Against dermatophytes and aspergillus naphthifin acts fungicidal.
In yeast fungi the drug has fungicidal or fungistatic activity depending on the strain of the microorganism. It has antibacterial activity against Gram-positive and Gram-negative microorganisms which may cause secondary bacterial infections. It has anti-inflammatory action, which contributes to the rapid disappearance of symptoms of inflammation, especially itching.
Pharmacokinetics
When applied externally, it penetrates the skin well, creating sustained antifungal concentrations in its various layers. After application on the skin less than 6% of naphthifin is absorbed systemically. Absorbed amount is partially metabolized and excreted by kidneys and intestine. Half-life of naphthifin is 2-3 days.
Indications
Active ingredient
Composition
The active ingredient:
Naphthyphine hydrochloride-10 mg.
Auxiliary substances:
Sodium hydroxide-1.2 mg,
Benzyl alcohol-10.0 mg,
sorbitan stearate – 19.0 mg,
cetyl palmitate – 20.0 mg,
cetyl alcohol – 40.0 mg,
stearic alcohol – 40.0 mg,
polysorbate 60-61.0 mg,
isopropyl myristate – 80.0 mg,
purified water – up to 1000 mg.
How to take, the dosage
Externally.
In case of skin lesions
The drug Naftifin is applied once a day on the affected skin surface and adjacent areas (approximately 1 cm of healthy skin at the edges of the affected area) after they have been thoroughly cleaned and dried.
The duration of therapy for dermatitis and goats is 2-4 weeks (up to 8 weeks if necessary); for candidiasis it is 4 weeks.
In case of nail lesions
The drug Naphtifine is applied 2 times a day on the affected nail. Before the first use, the affected part of the nail is removed as much as possible with scissors or a nail file.
The duration of therapy for onychomycosis is up to 6 months.
To prevent recurrence, treatment should be continued for at least 2 weeks after clinical symptoms have disappeared.
If there is no improvement after treatment or if new symptoms develop, you should consult a physician. Use the drug only according to the route of administration and in the dosage indicated in the instructions. If necessary, please talk to your doctor before using the medicine.
Interaction
Special Instructions
Naftifine is not intended for use in ophthalmology. The drug should not be allowed to get into the eyes.
Course treatment is required to achieve a therapeutic effect.
The effect of the drug on the ability to drive vehicles, machinery
The drug naphthifine has no adverse effect on the ability to drive vehicles and perform other activities requiring concentration and quick psychomotor reactions.
Contraindications
High sensitivity to naphthyphine, benzyl alcohol or other components of the drug. Pregnancy and breastfeeding (safety and effectiveness of use have not been established).
Cautions
Side effects
Overdose
Similarities
Weight | 0.025 kg |
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Shelf life | 5 years. |
Conditions of storage | At a temperature not higher than 30 ° C. Keep out of reach of children. |
Manufacturer | Tula Pharmaceutical Factory, Russia |
Medication form | exterior cream |
Brand | Tula Pharmaceutical Factory |
Other forms…
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