Mycophenolate Mofetil-TL, tablets 500 mg, 50 pcs.
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Mycophenolate Mofetil-TL has an immunosuppressive effect. It selectively inhibits inosine monophosphate dehydrogenase and inhibits guanosine nucleotide synthesis.
It has a pronounced cytostatic effect on lymphocytes, inhibits their proliferation, also inhibits antibody formation by B-lymphocytes.
Ingestion is quickly absorbed and completely hydrolyzed, forming mycophenolic acid.
It is mainly excreted by the kidneys. In combination with azathioprine and cyclosporine and with an induction course of antithymocyte globulin, it reduces the incidence of adverse outcomes in the first 6 months after transplantation.
Indications
Prevention of rejection reactions and treatment of allogeneic renal transplant rejection (in combination with cyclosporine A and glucocorticoids).
Active ingredient
Composition
1 capsule contains:
Active ingredients:
mycophenolate mofetil 500 mg
How to take, the dosage
It is used in combination therapy with cyclosporine and GCS.
In order to prevent graft rejection the first dose of mycophenolate mofetil is taken within the first 3 days after surgery.
When taken orally, the recommended dose is 2 g per day and the frequency of administration is 2 times per day.
For treatment of rejection reaction – 3 g per day.
Interaction
Probenecid and other drugs that affect tubular secretion increase the plasma concentration of mycophenolic acid.
Antacids containing magnesium and aluminum hydroxides decrease absorption. Drugs that alter the flora of the gastrointestinal tract may interfere with enterohepatic circulation.
Decreases the effectiveness of oral contraception.
Azathioprine increases the risk of lymphoma, especially of the skin.
Special Instructions
The possibility of increased risk of lymphoproliferative processes should be considered, peripheral blood counts should be monitored regularly, and if neutrophil counts decrease, a dose reduction or treatment interruption (and appropriate therapy) is indicated.
In case of decreased glomerular filtration rate below, it is not recommended to use more than 2 times a day. For more information, see the instructions for medical use of the drug.
Contraindications
Hypersensitivity, exacerbation of gastric and duodenal ulcer and other gastrointestinal diseases, pregnancy, breast-feeding, pediatric age.
Side effects
Nausea, vomiting, diarrhea, constipation, leukopenia or leukocytosis, anemia, thrombocytopenia, increased incidence of infectious and septic complications; headaches, insomnia, tremor, fever, asthenia, lumbago, hypertension, cough, pharyngitis, shortness of breath, peripheral edema, oropharyngeal candidiasis, hematuria, tubular necrosis, impotence, acne, hyper- or hypokalemia, hyperglycemia, hypophosphatemia, hypercholesterolemia, allergic reactions, rash, skin itching.
Overdose
Symptoms: increased incidence of gastrointestinal and hematological (particularly neutropenia) side effects.
Treatment: decrease the dose or stop the drug.
Bile acid sequestrants may be prescribed to accelerate excretion. Small amounts of glucuronide may be removed by hemodialysis (mycophenolic acid is not dialyzed).
Weight | 0.062 kg |
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Conditions of storage | In a dry, light-protected place at a temperature not exceeding 30 °C. |
Manufacturer | Drug Technology, Russia |
Medication form | pills |
Brand | Drug Technology |
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