Mycophenolate Mofetil-TL, 250 mg capsules, 100 pcs.
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Mycophenolate Mofetil-TL – Immunosuppressive agent; morpholinoethyl ester of mycophenolic acid produced by Penicillium stoloniferum.
Disrupts guanosine nucleotide synthesis by inhibiting inosine monophosphate dehydrogenase. Inhibits the proliferation of T- and B-lymphocytes and the production of antibodies.
Indications
Active ingredient
Composition
Active ingredients:
Mycophenolate mofetil250 mg
Ancillary substances:
Microcrystalline cellulose 0.065 g,
povidone K90 0.014 g,
croscarmellose sodium 0.0175 g,
magnesium stearate 0.0035 g.
Capsule contents:
Iron oxide black dye 0.0224 %, iron oxide red dye 0.0224 %, iron oxide yellow dye 0.4343 %, titanium dioxide 0.5265 %, gelatin to 100%.
Capsule cap composition:
Iron oxide dye black 0.7%, iron oxide red dye 0.07%, iron oxide yellow dye 0.5%, titanium dioxide 0.667%, gelatin to 100%
How to take, the dosage
It is used in combination therapy with cyclosporine and GCS.
In order to prevent graft rejection the first dose of mycophenolate mofetil is taken within the first 3 days after surgery.
When taken orally, the recommended dose is 2 g per day and the frequency of administration is 2 times per day. For treatment of rejection reaction – 3 g per day.
Interaction
Probenecid and other drugs that affect tubular secretion increase the plasma concentration of mycophenolic acid. Antacids containing magnesium and aluminum hydroxides reduce absorption. Drugs that change the flora of the gastrointestinal tract may interfere with enterohepatic circulation.
Decreases the effectiveness of oral contraception. Azathioprine increases the risk of lymphoma, especially of the skin.
Special Instructions
It is necessary to take into account the possibility of increasing the risk of lymphoproliferative processes, regularly monitor the composition of peripheral blood, in case of a decrease in neutrophil count a dose reduction or a break in treatment (and conducting appropriate therapy) is indicated.
In case of decreased glomerular filtration rate below this value, it is not recommended to use more than 2 times a day.
For more information, see the instructions for medical use of the drug.
Contraindications
A hypersensitivity to mycophenolate mofetil.
Side effects
Nausea, vomiting, diarrhea, constipation, leukopenia or leukocytosis, anemia, thrombocytopenia, increased incidence of infectious and septic complications; headaches, insomnia, tremor, fever, asthenia, lumbago, hypertension, cough, pharyngitis, shortness of breath, peripheral edema, oropharyngeal candidiasis, hematuria, tubular necrosis, impotence, acne, hyper- or hypokalemia, hyperglycemia, hypophosphatemia, hypercholesterolemia, allergic reactions, rash, skin itching.
Overdose
Symptoms: increased incidence of gastrointestinal and hematological (particularly neutropenia) side effects.
Treatment: decrease the dose or stop the drug.
Bile acid sequestrants may be prescribed to accelerate excretion.
Small amounts of glucuronide may be removed by hemodialysis (mycophenolic acid is not dialyzed).
Weight | 0.094 kg |
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Shelf life | 2 years |
Conditions of storage | In a dry, light-protected place at a temperature not exceeding 30 °C. Keep out of reach of children. |
Manufacturer | Drug Technology, Russia |
Medication form | capsules |
Brand | Drug Technology |
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