Mirapex PD, 0.375 mg 10 pcs

Mirapex PD is an antiparkinsonian drug – dopamine receptor agonist. With high selectivity and specificity it binds to dopamine receptors of subgroup D2, of which it has the most pronounced affinity for D3 receptors. Reduces motor deficits in Parkinson’s disease by stimulating dopamine receptors in the striatum. Pramipexole inhibits the synthesis, release and metabolism of dopamine. In vitro, pramipexole protects dopamine neurons from degeneration occurring in response to ischemia or methamphetamine neurotoxicity.

Pramipexole in vitro protects neurons from levodopa neurotoxicity.

Decreases prolactin secretion (dose-dependent).

In clinical studies in healthy volunteers in whom the dose of Mirapex PD was increased faster than necessary (every 3 days) up to 4.5 mg/day, an increase in BP and HR was observed. This effect was not observed in patient studies.

Pharmacokinetics

Intake and distribution

Pramipexole is quickly and completely absorbed after oral administration. Absolute bioavailability is greater than 90% and Cmax in plasma is reached after approximately 6 hours. As a rule, the bioavailability of pramipexole is not affected by food intake. After a fatty meal, there is a slight increase, approximately 20%, in Cmax and a delay, approximately 2 h, in the time to reach Cmax, which has no clinical significance.

Pramipexole exhibits linear kinetics and relatively little variability in plasma levels between patients, regardless of pharmaceutical form. Pramipexole binds very little to plasma proteins (

Metabolism and excretion

It is metabolized to a negligible degree.

About 90% of the dose is excreted through the kidneys (80% unchanged) and less than 2% is found in the feces. Total clearance of pramipexole is about 500 ml/min, renal clearance is about 400 ml/min. T1/2 fluctuates from 8 h in young adults to 12 h in the elderly.

Indications

Active ingredient

Composition

How to take, the dosage

Interaction

Special Instructions

Contraindications

Side effects

Overdose

Pregnancy use

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