Milk thistle interacts with free radicals in the liver and reduces their toxicity.
By interrupting the process of lipid peroxidation it prevents further destruction of cell structures.
In damaged hepatocytes it stimulates synthesis of structural and functional proteins and phospholipids (due to specific stimulation of RNA-polymerase A), stabilizes cell membranes, prevents loss of cellular components and intracellular enzymes (transaminases) and accelerates regeneration of liver cells.
Inhibits penetration into cells of some hepatotoxic substances (poisons of the pale grebes fungus). It is subjected to enterohepatic circulation. It is metabolized in the liver by conjugation.
Extracted mainly with bile in the form of glucuronides and sulfates, to a small extent with urine. It does not accumulate. After repeated oral administration of 140 mg 3 times a day a stable concentration is reached.
It improves general state of patients with liver diseases, decreases subjective complaints, normalizes laboratory indexes (activity of transaminases, gamma-glutamyltransferase, alkaline phosphate, bilirubin level).
Long-term use significantly increases survival rate of patients with cirrhosis.
- toxic liver damage (alcoholism, intoxication with halogen containing hydrocarbons, compounds of heavy metals, drug-induced liver damage) and their prevention;
- chronic hepatitis;
- Hepatic cirrhosis (as part of complex therapy);
- states after infectious and toxic hepatitis, liver dystrophy and fatty infiltration;
- correction of lipid metabolism disorders.
milk thistle extract (silymarin) + excipients
How to take, the dosage
Adults and children over 12 years: 0.5 teaspoons 2 times a day with meals. The course of treatment is 30 days.
When using milk thistle together with oral hormonal contraceptives and drugs intended for hormone replacement therapy, it is possible to reduce the effects of the latter.
Silymarin may increase the effects of diazepam, alprazolam, ketoconazole, lovastatin, vinblastine due to its inhibitory action on microsomal enzymes of cytochrome P450 system.
|Conditions of storage|
Store in a dry, light-protected place at a temperature not exceeding +25 ° C.
Biokor Ltd., Russia
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