Diacont test strips for glucometer, 50 pcs

Migrenol, tablets, 8 pcs.

Name: Migrenol, tablets, 8 pcs.
SKU: 99804
Availability: OutOfStock

€1.00

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EAN: 362487103088 SKU: 99804 Categories: Medicine, Pain and fever, Pain and fever relief

Description

Combination drug, the effect of which is determined by its constituent components

Caffeine has psychostimulant (stimulates the psychomotor centers of the brain), analeptic effect, enhances the effect of analgesics, eliminates sleepiness and fatigue, increases physical and mental performance.

Paracetamol has antipyretic and analgesic effect (due to inhibition of COX and inhibition of prostaglandin synthesis it affects the center of thermoregulation in the hypothalamus and the conduction of pain impulses in the CNS).

Pharmacokinetics

Paracetamol

Absorption is high, binding to plasma proteins – 15%. Time to reach maximum concentration (TC max ) – 20-30 min. It penetrates through the blood-brain barrier.

Less than 1% of the dose of paracetamol taken by a nursing mother passes into breast milk.

Therapeutically effective plasma concentrations of paracetamol are achieved when administered at a dose of 10-15 mg/kg.

Metabolized in liver: 80% reacts in conjugation with glucuronic acid and sulfates to form inactive metabolites: 17% undergoes hydroxylation to form active metabolites, which conjugate with glutathione and form inactive metabolites.

In glutathione deficiency these metabolites can block the enzyme systems of hepatocytes and cause their necrosis.

The elimination half-life (T 1/2 ) is 2-3 hours.

In elderly patients the drug clearance is decreased and T 1/2 is increased.

Extracted by the kidneys – 3% unchanged.

Caffeine

Tc mah – caffeine – 1h; T 1/2 – 3.5h; 65-80% of the drug is excreted mainly as 1-methylxanthine, 1-methylureic acid and acetylated derivatives of uracil a small amount is converted to theophylline and theobromine.

Indications

Myositis, Arthritis and arthritis, Myalgia (muscle pain), Headache, Neuralgia, Sinusitis, Painful menstruation (algodysmenorrhea), Flu, Neck pain, Joint pain (arthralgia), Toothache, Guillotine, Colds, Fever, Migraine, Pain

For mild to moderate pain relief:

Headache.
Migraine .
Toothache.
Muscular Pain.
Rheumatic Pain.
Muscle pain.
Painful menstruation.

For symptomatic treatment of colds and flu .

To reduce elevated body temperature.

Active ingredient

Caffeine, Paracetamol

Composition

1 tablet contains:

Active ingredients

Paracetamol 500.00 mg.
Caffeine 66.00 mg.

Auxiliary substances

Calcium hydrophosphate dihydrate,
.

Starch,

Microcrystalline cellulose,

Sodium carmellose,

magnesium stearate,

silicon dioxide,

Opady Clear YS-1-7006 (hypromellose + macrogol),

carnauba wax,

stearic acid.

How to take, the dosage
How to take, the dosage
I take Migrenol tablets orally, usually 1-2 tablets, if necessary 3-4 times a day. The interval between doses is at least 4 hours. The maximum single dose is 2 tablets, the maximum daily dose is 8 tablets.
The drug should not be used without prescription and medical supervision for more than 5 days if it is used as an analgesic and for more than 3 days as an antipyretic.
The indicated dose should not be exceeded. In case of overdose, it is necessary to consult a doctor immediately.

Interaction
Interaction
When taken for a long time, the drug increases the effect of indirect anticoagulants (warfarin and other coumarins), which increases the risk of bleeding.
Hepatic microsomal oxidation inducers (barbiturates, phenytoin, ethanol, rifampicin, phenylbutazone, tricyclic antidepressants) increase the risk of hepatotoxic effects in small overdoses.
Microsomal oxidation inhibitors (cimetidine) reduce the risk of hepatotoxic effects.
The elimination time of chloramphenicol is 5 times longer under the influence of paracetamol.
Caffeine accelerates absorption of ergotamine.
The simultaneous use of paracetamol and alcoholic beverages increases the risk of hepatotoxic effects and acute pancreatitis.
Metoclopramide and domperidone increase and colestyramine decreases the rate of absorption of paracetamol.
The drug may decrease the effectiveness of uricosuric drugs.
It enhances the effect of monoamine oxidase inhibitors.
.

Special Instructions
Special Instructions
Excessive consumption of caffeine-containing products (coffee, tea) during treatment may cause overdose symptoms. During treatment, avoid work requiring quick reaction and concentration, do not use alcohol and other CNS inhibitors.
Peripheral blood count and liver function monitoring are required during long-term treatment.
Impact on the ability to drive and operate machinery
The drug Migrenol may cause decreased speed of motor reactions. During treatment, avoid work requiring fast reactions and concentration.
.

Contraindications
Contraindications
High sensitivity to the ingredients of the drug.
Veep hepatic and hepatic dysfunction.
Childhood (under 12 years).
Genetic absence of glucose-6-phosphate dehydrogenase.
Developed arterial hypertension
Developed atherosclerosis
Epilepsy .
Pregnancy.
Period of breastfeeding.
With caution should be used when:
Hilbert’s syndrome and other benign hyperbilirubinemia.
Glaucoma.
Sleep disorders.

Side effects
Side effects
The drug is usually well tolerated in the recommended doses.
Allergic reactions (skin rash, pruritus, urticaria, Quincke’s edema).
Essudative erythema (including Stevens-Johnson syndrome).
Toxic epidermal necrolysis (Lyell’s syndrome).
Dizziness.
Nausea.
Epigastric pain.
Hemolytic anemia.
Trombocytopenia.
Agranulocytosis.
Insomnia.
In prolonged use at high doses
Hepatotoxic effects, hemolytic anemia, aplastic anemia, methemoglobinemia, pancytopenia, nephrotoxicity.
.

Overdose
Overdose
Symptoms: nausea, vomiting, stomach pain, pale skin, anorexia. Hepatonecrosis (severity of necrosis due to intoxication directly depends on the degree of overdose), the unfolded clinical picture of liver damage is manifested in 1-6 days.
Treatment: gastric lavage and adsorbents (activated charcoal). If an overdose is suspected, seek medical attention immediately.

Similarities
Similarities
Solpadein Fast, Migrenium

Additional information
Weight 0.018 kg
Shelf life
3 years
Conditions of storage
In a dry, light-protected place at a temperature below 25 °C
Manufacturer
Fore Ventures, USA
Medication form
pills
Brand
Fore Ventures