Midantan, 100 mg 100 pcs

How to take, the dosage

Parkinson’s disease, parkinsonism syndrome: Amantadine is prescribed in an initial dose of 100 mg daily for the first week, then the dose is increased to 100 mg twice daily.

The necessary dose should be established depending on the severity of the symptoms of parkinsonism and the tolerability of the drug. A dose in excess of 200 mg daily may provide some additional effect, but is associated with an increased risk of toxicity. The dose of 400 mg per day should not be exceeded.

The daily dose should be increased gradually, at intervals of at least one week. Because patients over 65 years of age usually have reduced renal function and therefore higher plasma concentrations of amantadine, these patients should be prescribed the lowest dose that results in the desired effect.

The withdrawal of amantadine should be done gradually, that is, the dose should be reduced in half at one-week intervals. Abrupt withdrawal of amantadine may worsen the symptoms of parkinsonism, regardless of the patient’s response to ongoing therapy.

Interaction

Drugs that stimulate the central nervous system and ethanol increase the risk of side effects. Increases the effect of levodopa, psychostimulants. Compatible with central cholinolytics and other anti-Parkinsonian drugs.

Special Instructions

There is conflicting information about the efficacy in the treatment of extrapyramidal disorders with antipsychotic treatment (drug-induced parkinsonism). Therapy should not be stopped abruptly, because a sharp exacerbation of the disease is possible. Using ethanol while taking the drug is contraindicated.

When taking the drug, it is necessary to refrain from driving and engaging in potentially dangerous activities requiring increased concentration and quick psychomotor reactions.

Contraindications

Hepatic failure, chronic renal failure, psychosis (including history), thyrotoxicosis, epilepsy, closed-angle glaucoma, prostatic hyperplasia, arterial hypotension, chronic heart failure stage II-III, agitation state, predelirium, delirium psychosis, pregnancy planning,

Pregnancy, lactation, concomitant use of triamterene and hydrochlorothiazide, peptic ulcer or duodenal ulcer in anamnesis, hypersensitivity to amantadine or other components of the medicine, children under 18 years of age.

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Side effects

Nervous system disorders: motor or mental agitation, seizures, headache, dizziness, irritability, insomnia, tremor, mental disorders accompanied by visual hallucinations.

Cardiovascular system: heart failure, tachycardia, orthostatic hypotension, arrhythmogenic effect.

Digestive system disorders: dry mouth, nausea, anorexia, dyspepsia.

Uses of the urinary system: acute urinary retention in patients with prostatic hyperplasia, polyuria, nycturia.

Others: dermatosis, occurrence of bluish coloring of the skin of the upper and lower extremities, decreased visual acuity.

Pregnancy use

It is contraindicated in pregnancy (I trimester) and during lactation. Take with caution in the second and third trimesters of pregnancy.

Similarities

PC-Merz