Mexib 6, 125 mg+10 mg 30 pcs

Cardialgia (heart pain), Atherosclerosis, Neurosis, Dizziness, Vascular disorders, Asthenia, Impaired cerebral circulation, Exposure to adverse factors

In the combined therapy:

• discirculatory encephalopathy;
• syndrome of autonomic dystonia;
• anxiety in neurotic and neurosis-like states;
• abstinence syndrome in alcoholism with predominance of neurosis-like and vegetative-vascular disorders;
• Absicion syndrome in alcoholismischemic heart disease (prevention of attacks);
• states after acute intoxication with antipsychotic drugs
• sthenic conditions, and to prevent the development of somatic diseases under the influence of extreme factors and loads
• exposure to extreme (stress) factors.

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Composition

Drug form:

film-coated tablets

Composition:

1 film-coated tablet contains:

Active substances:

ethylmethylhydroxypyridine succinate 125 mg,

pyridoxine hydrochloride 10 mg;

Associates:

calcium hydrophosphate dihydrate, copovidone (collidone VA-64 or Plasdon ES-630),

colloidal silicon dioxide (aerosil),

croscarmellose sodium (primellose),

magnesium lactate, magnesium stearate,

hydrogenated castor oil,

microcrystalline cellulose;

Composition of the film coating:

Selecoat AQ-02003 [hypromellose (hydroxypropyl methylcellulose),macrogol (polyethylene glycol 6000), titanium dioxide].

How to take, the dosage

Overly, 1 tablet 3 times a day; the initial dose is 1-2 tablets 1-2 times a day with gradual increase until therapeutic effect.

The maximum daily dose is 6 tablets/day.

The duration of treatment is 2-8 weeks. If necessary repeated courses are possible.

Interaction

It enhances the effect of benzodiazepine anxiolytics, antiepileptic drugs (carbamazepine), anti-Parkinsonian drugs (levodopa), nitrates.

Reduces the toxic effects of ethanol.

It enhances the effect of diuretics; it combines well with cardiac glycosides (pyridoxine promotes the synthesis of contractile proteins in the myocardium), with glutamic acid and potassium and magnesium asparaginate (increases resistance to hypoxia).

Pyridoxine is pharmaceutically incompatible with thiamine and cyanocobalamin. Isoniazid, penicillamine, cycloserine and estrogen-containing oral contraceptives weaken the effect of pyridoxine.

Special Instructions

When treating, caution should be exercised when driving motor vehicles and engaging in other potentially dangerous activities that require increased concentration and quick psychomotor reactions.

Contraindications

Hypersensitivity; acute hepatic and/or renal failure; pregnancy, lactation, childhood.

With caution

Gastric and 12 duodenal ulcer.

Side effects

Nausea, dry mouth, diarrhea, drowsiness, allergic reactions, hypersecretion of hydrochloric acid (HCl), numbness, feeling of compression in the extremities – the symptom of “stockings” and “gloves”, reduced lactation (sometimes used as a therapeutic effect).

Overdose

Symptoms: sleep disturbances (insomnia, in some cases drowsiness).

Treatment is usually not required – symptoms disappear on their own within 24 hours. In severe cases of insomnia – nitrazepam 10 mg, oxazepam 10 mg or diazepam 5 mg.