Memantal, 10 mg 60 pcs

The drug for the treatment of dementia.

It is a non-competitive antagonist of glutamate NMDA-receptors (including in the substantia nigra), due to this it reduces excessive stimulating effect of cortical glutamate neurons on neostriatum, which develops on the background of insufficient dopamine release.

By reducing the Ca2+ influx into neurons, it reduces the possibility of their destruction. It has nootropic, cerebrovasodilatory, antihypoxic and psychostimulatory effects.

It improves impaired memory, increases ability to concentrate, reduces fatigue and symptoms of depression, reduces spasticity of skeletal muscles caused by diseases or brain damage.

Indications

Moderate to severe dementia due to Alzheimer’s disease.

Pharmacological effect

A drug for the treatment of dementia.

It is a non-competitive antagonist of glutamate NMDA receptors (including in the substantia nigra), as a result of which it reduces the excessive stimulating effect of cortical glutamate neurons on the neostriatum, which develops against the background of insufficient dopamine release.

By reducing the flow of Ca2+ into neurons, it reduces the possibility of their destruction. It has nootropic, cerebrovasodilating, antihypoxic and psychostimulating effects.

Improves weakened memory, increases the ability to concentrate, reduces fatigue and symptoms of depression, reduces skeletal muscle spasticity caused by diseases or damage to the brain.

Special instructions

Use with caution in patients with epilepsy, renal failure, thyrotoxicosis, a history of seizures, arterial hypertension, a history of myocardial infarction, or heart failure. If renal function is impaired, the dose of memantine should be reduced.

For renal impairment Contraindicated in renal failure. If renal function is impaired, the dose of memantine should be reduced.

Active ingredient

Memantine

Composition

Film-coated tablets 1 tablet active substance:

memantine hydrochloride 10 mg

excipients

core:

lactose monohydrate – 149.75 mg; MCC – 27.1 mg; talc – 11.15 mg; colloidal silicon dioxide – 1.25 mg; magnesium stearate – 0.75 mg

film shell:

Opadry® white (lactose monohydrate – 2.16 mg, hypromellose – 1.68 mg, titanium dioxide – 1.56 mg, macrogol 4000 – 0.6 mg) – 6 mg

Contraindications

Severe liver failure; pregnancy; lactation period (breastfeeding); children and adolescents under 18 years of age (the effectiveness and safety of the drug have not been studied); hypersensitivity to memantine.

Side Effects

From the nervous system: dizziness, headache, drowsiness, gait disturbance, confusion, hallucinations, convulsions, psychosis, increased excitability.

From the digestive system: constipation, vomiting, nausea, pancreatitis.

From the cardiovascular system: increased blood pressure, venous thrombosis, thromboembolism.

From the body as a whole: fungal infections, general weakness, increased fatigue, allergic reactions.

Interaction

When used concomitantly, memantine can reduce the effects of barbiturates and antipsychotics. The effects of baclofen and dantrolene may be altered by memantine (dose adjustment may be required with this combination). The effects of levodopa, dopamine receptor agonists and anticholinergics are enhanced by concomitant use of NMDA receptor antagonists.

Due to the fact that memantine and amantadine are NMDA receptor antagonists, simultaneous use should be avoided due to the risk of toxic effects. Combinations of memantine with ketamine, dextromethorphan and phenytoin are also potentially toxic.

The same renal cationic system is used to transport amantadine, cimetidine, ranitidine, quinidine, quinine and nicotine in the body, which may cause the interaction of these drugs with memantine, leading to an increase in its concentration in the blood plasma.

When used concomitantly, memantine may cause a decrease in the concentration of hydrochlorothiazide in the blood serum. When used simultaneously with warfarin and other indirect anticoagulants, careful monitoring of prothrombin time and INR is required.

Manufacturer

Sinton Spain S.L., Spain