Meldonium, 500 mg capsules 60 pcs

Meldonium is an analogue of gamma-butyrobetaine, inhibits gamma-butyrobe-tainhydroxinase, reduces carnitine synthesis and transport of long-chain fatty acids through cell membranes, prevents the accumulation of activated forms of unoxidized fatty acids in cells – derivatives of acylcarnitine and acylkoenzyme A. As a result of reducing the concentration of carnitine gamma-butyrobetaine, which has vasodilatory properties, is synthesized intensively.

In ischemia conditions it restores equilibrium of oxygen delivery and consumption in cells, prevents the violation of ATP transport, and simultaneously activates glycolysis, which proceeds without additional oxygen consumption.

The mechanism of action determines the diversity of its pharmacological effects: increase efficiency, reduction of symptoms of mental and physical stress, activation of tissue and humoral immunity, cardioprotective effect. In acute ischemic myocardial injury slows the formation of necrotic zone, shortens the rehabilitation period.

In heart failure increases myocardial contractility, increases exercise tolerance, reduces the frequency of angina attacks. In acute and chronic ischemic cerebral circulatory disorders it improves blood circulation in ischemic area and redistributes the blood in favor of ischemic area.

Effective in cases of vascular and dystrophic eye fundus pathology. Tonic effect on the central nervous system, elimination of functional disorders of somatic and vegetative nervous systems in patients with alcoholism during withdrawal are also characteristic.

Indications

In the combination therapy of coronary heart disease, chronic heart failure, cardialgia against myocardial dystrophy.

Disorders of the blood supply of the brain (stroke, cerebrovascular insufficiency). Complex therapy of withdrawal alcohol syndrome.

Disabled performance, chronic physical overexertion, postoperative period to accelerate rehabilitation processes.

Active ingredient

Composition

How to take, the dosage

Overly, before meals.

Stable angina pectoris, chronic heart failure – as part of complex therapy at 500-1000 mg a day, using the whole dose at once or dividing it into 2 times. The course of treatment is 4-6 weeks.

Cardialgia against myocardial dyshormonal dystrophy: 250 mg 2 times a day (in the morning and in the evening). The course of treatment is 12 days.

Brain blood supply disorders (stroke, cerebrovascular insufficiency) – 500-1000 mg per day, preferably in the morning. The course of treatment is 4-6 weeks. Withdrawal alcohol syndrome – 500 mg 4 times a day. The course of treatment is 7-10 days.

With decreased performance and chronic physical stress, in the postoperative period to accelerate the rehabilitation – 250 mg 4 times a day. The course of treatment is 10-14 days. If necessary, treatment should be repeated in 2-3 weeks. Sportsmen are prescribed 500-1000 mg 2 times a day before training. Course duration during the preparatory period – 14-21 days during competition – 10-14 days.

Interaction

Special Instructions

Contraindications

Side effects

Pregnancy use

Similarities