Melarena, 0.3 mg 30 pcs

Synthetic analogue of the pineal body hormone (epiphysis) melatonin; has adaptogenic, sedative, and hypnotic effects. It normalizes circadian rhythms.

Increases the concentration of gamma-aminobutyric acid (GABA) and serotonin in the midbrain and hypothalamus, changes the activity of pyridoxal kinase, involved in the synthesis of GABA, dopamine and serotonin.

Regulates the sleep-wake cycle, daily changes in locomotor activity and body temperature, has a positive effect on the intellectual and mental functions of the brain, on the emotional and personality sphere.

Promotes the organization of the biological rhythm and the normalization of night sleep. It improves the quality of sleep, accelerates falling asleep, reduces the number of night awakenings, improves the sense of well-being upon awakening, does not cause a feeling of dullness, weariness and fatigue upon awakening.

Makes dreams more vivid and emotionally rich.

Adapts the body to rapid change of time zones, reduces stress reactions, regulates neuroendocrine functions. Adapts the body of people sensitive to changes in weather conditions.

It shows immunostimulating and antioxidant properties. Inhibits secretion of gonadotropins, to a lesser extent – other adenohypophysis hormones (corticotropin, thyroid hormone, somatotropic hormone). It is not addictive and not dependent.

Pharmacokinetics

When administered orally it is quickly and completely absorbed, easily passes through the histo-hematic barriers including the blood-brain barrier. It has a short half-life.

Indications

Active ingredient

Composition

How to take, the dosage

Interaction

Incompatible with monoamine oxidase inhibitors (MAOIs), glucocorticosteroids, cyclosporine.

Increases the effect of drugs that depress the central nervous system and beta-adrenoblockers.

It is not recommended to take simultaneously with nonsteroidal anti-inflammatory drugs (NSAIDs).

It is not recommended to take together with hormonal drugs.

Special Instructions

Synopsis

Features

Contraindications

Hypersensitivity to melatonin and other drug components; autoimmune diseases, allergic diseases; lymphogranulematosis, leukemia, lymphoma, myeloma, epilepsy, diabetes, chronic renal

deficiency; severe renal dysfunction (for 3 mg dosage); pregnancy, breastfeeding; age under 18 years (efficacy and safety of use have not been established).

Application during pregnancy and lactation

The drug is contraindicated during pregnancy and lactation.

Side effects

Overdose

There are no data on cases of melatonin overdose. Increased dose-dependent adverse reactions are possible.

Treatment: gastric lavage, symptomatic therapy.

Pregnancy use

Similarities