Magnet B6, 100 pcs.

Magnesium is a vital element that is found in all tissues of the body and is necessary for normal functioning of cells and is involved in most metabolic reactions.

In particular, it is involved in the regulation of nerve impulse transmission and muscle contraction. The body receives magnesium with food. Lack of magnesium in the body may be observed in violation of the diet (diet) or increased need for magnesium (with increased physical and mental load, stress, pregnancy, use of diuretics).

Pyridoxine (vitamin B6) is involved in many metabolic processes in the regulation of metabolism of the nervous system. Vitamin B6 improves the absorption of magnesium from the gastrointestinal tract and its penetration into cells. Serum magnesium content: – 12 to 17 mg/L (0.5 to 0.7 mmol/L) indicates moderate magnesium deficiency; – below 12 mg/L (0.5 mmol/L) indicates severe magnesium deficiency.

Pharmacokinetics

Magnesium absorption in the gastrointestinal tract is no more than 50% of the oral dose. 99% of the body’s magnesium is intracellular. Approximately 2/3 of intracellular magnesium is distributed in bone tissue, and the other 1/3 is in smooth and striated muscle tissue. Magnesium is excreted mainly in the urine. At least 1/3 of the dose of magnesium taken is excreted with urine.

Indications

Established magnesium deficiency, isolated or associated with other deficiency conditions, accompanied by symptoms such as: increased irritability, minor sleep disturbances; gastrointestinal cramps or palpitations; increased fatigue, muscle aches and spasms, tingling sensation.

Active ingredient

Magnesium, Pyridoxine

Interaction

Combinations contraindicated
– With levodopa: levodopa activity is inhibited by pyridoxine (if taking this drug is not combined with taking peripheral aromatic L-amino acid decarboxylase inhibitors). Any amount of pyridoxine should be avoided unless levodopa is taken in combination with peripheral aromatic L-amino acid decarboxylase inhibitors.

Unrecommended combinations
– Concurrent use of drugs containing phosphates or calcium salts may impair intestinal absorption of magnesium.

Combinations to be taken into account
– When prescribing oral tetracyclines, an interval of at least three hours between oral tetracycline and Magnesium B6® should be observed, because magnesium preparations reduce absorption of tetracyclines.

Directions for use

Before taking the drug, you should consult with your doctor.

Special Instructions

Information for diabetics: coated tablets contain sucrose as an excipient. In case of severe magnesium deficiency or malabsorption syndrome, treatment is started with intravenous magnesium preparations. In case of concomitant calcium deficiency, it is recommended to eliminate magnesium deficiency before taking calcium preparations or food supplements containing calcium. Frequent use of laxatives, alcohol, strenuous physical and mental stress increases the need for magnesium, which can lead to magnesium deficiency in the body.

Contraindications

– Hypersensitivity to the drug components.
– Severe renal insufficiency (creatinine clearance less than 30 ml/minute).
– Phenylketonuria.
– Children under 6 years of age (for the drug in tablet form) and under 1 year (for the solution).
– Fructose intolerance, glucose-galactose malabsorption syndrome, sucrose-isomaltase deficiency (only for the preparation in tablet form due to the presence of sucrose).
– Simultaneous use of levodopa (see section “Interaction with other medicinal products”).
Caution In moderate renal insufficiency, since there is a risk of hypermagnesemia.

Side effects

Immune system disorders Very rare (< 0.01%): allergic reactions, including skin reactions.

Overdose

Under normal renal function, magnesium overdose when taken orally does not usually result in toxic reactions. However, in the case of renal failure, magnesium poisoning may develop.

Pregnancy use

Clinical experience of using the drug in a sufficient number of pregnant women did not reveal any adverse effects on fetal malformations or fetotoxic effects.

Similarities

Magnes B6 forte, Magnelis B6 forte, Magnelis B6