Magnet B6, 100 pcs.

Magnesium is a vital element that is found in all tissues of the body and is necessary for normal functioning of cells and is involved in most metabolic reactions.

In particular, it is involved in the regulation of nerve impulse transmission and muscle contraction. The body receives magnesium with food. Lack of magnesium in the body may be observed in violation of the diet (diet) or increased need for magnesium (with increased physical and mental load, stress, pregnancy, use of diuretics).

Pyridoxine (vitamin B6) is involved in many metabolic processes in the regulation of metabolism of the nervous system. Vitamin B6 improves the absorption of magnesium from the gastrointestinal tract and its penetration into cells. Serum magnesium content: – 12 to 17 mg/L (0.5 to 0.7 mmol/L) indicates moderate magnesium deficiency; – below 12 mg/L (0.5 mmol/L) indicates severe magnesium deficiency.

Pharmacokinetics

Magnesium absorption in the gastrointestinal tract is no more than 50% of the oral dose. 99% of the body’s magnesium is intracellular. Approximately 2/3 of intracellular magnesium is distributed in bone tissue, and the other 1/3 is in smooth and striated muscle tissue. Magnesium is excreted mainly in the urine. At least 1/3 of the dose of magnesium taken is excreted with urine.

Indications

Established magnesium deficiency, isolated or associated with other deficiency conditions, accompanied by symptoms such as: increased irritability, minor sleep disturbances; gastrointestinal cramps or rapid heartbeat; increased fatigue, pain and muscle spasms, tingling sensation.

Pharmacological effect

Magnesium is a vital element that is found in all tissues of the body and is necessary for the normal functioning of cells and is involved in most metabolic reactions.

In particular, it is involved in the regulation of the transmission of nerve impulses and muscle contraction. The body receives magnesium through food. A lack of magnesium in the body can occur when the diet is disrupted or when the need for magnesium increases (with increased physical and mental stress, stress, pregnancy, use of diuretics).

Pyridoxine (vitamin B6) is involved in many metabolic processes and in the regulation of nervous system metabolism. Vitamin B6 improves the absorption of magnesium from the gastrointestinal tract and its penetration into cells. Serum magnesium content: – from 12 to 17 mg/l (0.5 – 0.7 mmol/l) indicates moderate magnesium deficiency; – below 12 mg/l (0.5 mmol/l) indicates severe magnesium deficiency.

Pharmacokinetics

Absorption of magnesium in the gastrointestinal tract is no more than 50% of the dose taken orally. 99% of magnesium in the body is found inside cells. Approximately 2/3 of intracellular magnesium is distributed in bone tissue, and the other 1/3 is in smooth and striated muscle tissue. Magnesium is excreted primarily in the urine. At least 1/3 of the administered dose of magnesium is excreted in the urine.

Special instructions

Information for patients with diabetes mellitus: film-coated tablets contain sucrose as an excipient. In case of severe magnesium deficiency or malabsorption syndrome, treatment begins with intravenous administration of magnesium preparations. In case of concomitant calcium deficiency, it is recommended to correct the magnesium deficiency before taking calcium supplements or dietary supplements containing calcium. With frequent use of laxatives, alcohol, intense physical and mental stress, the need for magnesium increases, which can lead to the development of magnesium deficiency in the body.

Active ingredient

Magnesium, Pyridoxine

Composition

Tablet core:

Pregnancy

Clinical experience with the use of the drug in a sufficient number of pregnant women has not revealed any adverse effects on the occurrence of fetal malformations or fetotoxic effects.

Contraindications

– Hypersensitivity to the components of the drug.
– Severe renal failure (creatinine clearance less than 30 ml/minute).
– Phenylketonuria.
– Children’s age up to 6 years (for the drug in tablet form) and up to 1 year (for solution).
– Fructose intolerance, glucose-galactose malabsorption syndrome, sucrase-isomaltase deficiency (only for the drug in tablet form due to the presence of sucrose in the composition).
– Simultaneous use of levodopa (see section “Interaction with other drugs”).
With caution In case of moderate renal failure, as there is a risk of developing hypermagnesemia.

Side Effects

Immune system disorders Very rare (<0.01%): allergic reactions, including skin reactions.

Interaction

Contraindicated combinations
– With levodopa: the activity of levodopa is inhibited by pyridoxine (unless this drug is combined with peripheral aromatic L-amino acid decarboxylase inhibitors). Any amount of pyridoxine should be avoided unless levodopa is taken in combination with peripheral aromatic L-amino acid decarboxylase inhibitors.

Not recommended combinations
– Concomitant use of drugs containing phosphates or calcium salts may impair the absorption of magnesium in the intestine.

Combinations to consider
– When prescribing tetracyclines orally, it is necessary to maintain an interval of at least three hours between ingestion of tetracycline and Magne B6®, since magnesium preparations reduce the absorption of tetracyclines.

Overdose

With normal renal function, an overdose of magnesium when taken orally usually does not lead to toxic reactions. However, in case of renal failure, magnesium poisoning may develop.

Recommendations for use

Before taking the drug, you should consult your doctor.

Storage conditions

Film-coated tablets: in a dry place, protected from light at a temperature not exceeding 25°C

Shelf life

2 years.

Manufacturer

Hinoine Pharmaceutical and Chemical Plant, Hungary