Magnesium sulfate, 20 g

Pharmacodynamics

Parenteral administration has a CNS depressant effect. Depending on the dose, sedative, hypnotic or narcotic effect may be observed.

Magnesium sulfate has a suppressive effect on neuromuscular transmission. It decreases excitability of the respiratory center; in high doses when administered parenterally it may cause respiratory paralysis.

Lower blood pressure, including in connection with a general sedative effect (the effect is more pronounced in hypertension). Magnesium sulfate is excreted by the kidneys; in the process of excretion diuresis is increased.

The antagonists of magnesium ion are calcium ions. A decrease in calcium in the blood is accompanied by an increase in the action of magnesium.

Indications

Composition

Active substance:

Magnesium sulfate

How to take, the dosage

Ingestion.

Adults – 15-25 g once a day on an empty stomach, previously dissolving the drug in a glass of water (250 ml).

Children over 12 years of age – 10 g once a day (in 1/2 cup of water).

Children at the age of 6-12 years – from 5 to 10 g (i.e. from half to whole volume of the solution prepared at the rate of 10 g per 1/2 cup of water).

In children under 6 years of age the drug can be used only by prescription.

Daily doses are determined at the rate of 1 g per 1 year of life.

The drug can be used in the form of enemas (50-100 ml of 20-30% solution).

Contraindications

Overdose

Symptoms: possible respiratory depression, CNS depression, up to the development of narcosis.

Treatment: as an antidote in case of magnesium sulfate overdose use calcium preparations – calcium chloride or calcium gluconate.