Magnerot, tablets 500 mg 50 pcs
€20.34 €16.95
Pharmacotherapeutic group: magnesium drug
ATC code: A12CC09
Pharmacological properties
Pharmacodynamics
Magnesium drug. It is the most important macronutrient, magnesium performs more than 300 enzymatic reactions, regulation of cell permeability and neuromuscular excitability. Necessary for many energy processes, is involved in the metabolism of proteins, fats, carbohydrates and nucleic acids. Magnesium has a curare-like effect on the terminations of cholinergic neurons, with a decrease in acetylcholine release; magnesium and calcium interact partly synergistically in the body; however, while competitively inhibiting calcium, magnesium can also affect its binding sites as a “physiological calcium antagonist”.
Pharmacokinetics
The absorption is approximately 35-40% of the administered dose. Hypomagnesemia stimulates absorption of magnesium ions. The presence of orotic acid salts promotes magnesium absorption.
Magnesium is excreted by the kidneys, excretion decreases in magnesium deficiency and increases in magnesium excess.
Indications
An established magnesium deficiency, isolated or associated with other deficiency conditions, accompanied by symptoms such as increased irritability, minor sleep disturbances, gastrointestinal cramps, increased fatigue, muscle aches and spasms, tingling sensation in muscles.
If there is no reduction in these symptoms after one month of treatment, continuation of treatment is not advisable.
Active ingredient
Composition
Per 1 tablet:
Active ingredient: magnesium orotate dihydrate – 500 mg;
Excipients: colloidal silica, croscarmellose sodium, microcrystalline cellulose, corn starch, povidone-K30, lactose monohydrate, sodium cyclamate, talc, magnesium stearate.
How to take, the dosage
Two tablets 3 times a day for 7 days, then one tablet 2-3 times a day daily. The duration of the course of treatment – 4 weeks. Treatment should be discontinued immediately after normalization of magnesium concentration in blood.
Interaction
In concomitant administration of magnesium-containing drugs with preparations of iron, sodium fluoride and tetracyclines may reduce absorption of the latter. In addition, aminoquinolines, quinidine, penicillamine should not be administered simultaneously with magnesium preparations. Therefore, these drugs should be taken 2-3 hours apart. Oral contraceptives, diuretics, muscle relaxants, glucocorticosteroids, insulin reduce the effect of the drug.
Magnesium should be used with caution if you are taking magnesium-containing medications such as antacids or laxatives, or potassium-saving diuretics or calcium-containing medications. When used concomitantly with drugs containing aluminum, aluminum absorption in the body may be increased.
Magnesium should be used with caution when used concomitantly with foxglove drugs because concomitant use may impair absorption of foxglove drugs.
Some antibiotics (aminoglycosides), cisplatin and cyclosporine A may lead to increased magnesium excretion.
Some diuretics (thiazides and furosemide), cetuximab and erlotinib, proton pump inhibitors (omeprazole and pantoprazole), foscarnet, pentamidine, rapamycin and amphotericin B may cause magnesium deficiency and thus lead to a reduced effect of Magnerot®.
Special Instructions
The drug contains lactose monohydrate, therefore its use is not recommended in patients with hereditary galactosemia, glucose and galactose malabsorption syndrome or lactase deficiency.
Impact on ability to drive vehicles, operate machinery
The drug does not affect the ability to drive vehicles and operate machinery.
Synopsis
White or nearly white round flat tablets with a bevel on both sides and a groove on one side.
Contraindications
Hypersensitivity to the ingredients of the drug, urolithiasis, renal function disorders, predisposition to formation of calcium-magnesium-ammonium-phosphate stones, myasthenia gravis, atrioventricular block, cirrhosis with ascites, childhood age under 18 years, lactose intolerance, lactase deficiency or glucose-galactose malabsorption (due to the presence of lactose in the drug).
Side effects
The incidence of adverse reactions cannot be determined on the basis of available data.
Gastrointestinal disorders: unsteady stools and diarrhea, which go away on their own with reduction of the drug dose.
Immune system disorders: allergic reactions.
If any of the side effects listed in the instructions worsen, or if you notice any other side effects not listed in the instructions, tell your doctor.
Overdose
In normal renal function, ingestion of magnesium does not cause toxic reactions. Magnesium poisoning may develop in renal failure. Toxic effects mainly depend on the concentration of magnesium in the blood serum.
Symptoms: decreased blood pressure, nausea, vomiting, depression, slowed reflexes, respiratory depression, coma, cardiac arrest, anuric syndrome.
Treatment: rehydration, forced diuresis, with renal failure hemodialysis or peritoneal dialysis is necessary.
Pregnancy use
The drug Magnerot® can be used during pregnancy only on the doctor’s recommendation.
Magnesium penetrates into the breast milk. The use of the drug during breastfeeding should be avoided.
The use of the drug during pregnancy and lactation is possible if the potential benefit to the mother exceeds the potential risk to the fetus and child.
Similarities
Weight | 0.051 kg |
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Shelf life | 5 years |
Conditions of storage | At a temperature not exceeding 25 ° C. Store out of the reach of children. |
Manufacturer | Pik-Pharma Lek, Russia |
Medication form | pills |
Brand | Pik-Pharma Lek |
Other forms…
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