Magnerot, tablets 500 mg 100 pcs

Pharmacotherapeutic group: magnesium drug

ATX code: A12CC09

Pharmacological properties

Pharmacodynamics

Magnesium drug. It is the most important macronutrient, magnesium performs more than 300 enzymatic reactions, regulation of cell permeability and neuromuscular excitability. Necessary for many energy processes, is involved in the metabolism of proteins, fats, carbohydrates and nucleic acids. Magnesium has a curare-like effect on the terminations of cholinergic neurons, with a decrease in acetylcholine release; magnesium and calcium interact partly synergistically in the body; however, while competitively inhibiting calcium, magnesium can also affect its binding sites as a “physiological calcium antagonist”.

Pharmacokinetics

The absorption is approximately 35-40% of the administered dose. Hypomagnesemia stimulates absorption of magnesium ions. The presence of orotic acid salts promotes magnesium absorption.

Magnesium is excreted by the kidneys, excretion decreases in magnesium deficiency and increases in magnesium excess.

Indications

Established magnesium deficiency, isolated or associated with other deficiency conditions, accompanied by symptoms such as increased irritability, minor sleep disturbances, gastrointestinal cramps, increased fatigue, muscle pain and spasms, and a tingling sensation in the muscles.
If after a month of treatment there is no improvement in these symptoms, continuing treatment is not advisable.

Pharmacological effect

Pharmacotherapeutic group: magnesium preparation

ATX code: A12CC09

Pharmacological properties

Pharmacodynamics

Magnesium preparation. An essential macronutrient, magnesium carries out more than 300 enzymatic reactions, regulates cellular permeability and neuromuscular excitability. Necessary for many energy processes, participates in the metabolism of proteins, fats, carbohydrates and nucleic acids. Magnesium has a curare-like effect on the terminals of cholinergic neurons, with a decrease in the release of acetylcholine; magnesium and calcium interact in the body partially synergistically; however, when competitively inhibiting calcium, magnesium can also affect its binding sites as a “physiological calcium antagonist.”

Pharmacokinetics

Approximately 35-40% of the dose taken is absorbed. Hypomagnesemia stimulates the absorption of magnesium ions. The presence of orotic acid salts improves the absorption of magnesium.

Magnesium is excreted by the kidneys; excretion decreases with magnesium deficiency and increases with its excess.

Special instructions

The drug contains lactose monohydrate, therefore its use is not recommended for patients with hereditary galactosemia, glucose-galactose malabsorption syndrome or lactase deficiency.

Impact on the ability to drive vehicles and machinery

The drug does not affect the ability to drive vehicles or operate machinery.

Active ingredient

Magnesium orotate

Composition

Composition per 1 tablet:

Active ingredient: magnesium orotate dihydrate – 500 mg;

Excipients: colloidal silicon dioxide, croscarmellose sodium, microcrystalline cellulose, corn starch, povidone-K30, lactose monohydrate, sodium cyclamate, talc, magnesium stearate.

Pregnancy

The tablets are taken orally before meals with a small amount of water.
2 tablets 3 times a day for 7 days, then 1 tablet 2-3 times a day daily. The duration of treatment is 4 weeks. Treatment should be stopped immediately after normalization of magnesium concentration in the blood.

Contraindications

Hypersensitivity to the components of the drug, urolithiasis, renal dysfunction, predisposition to the formation of calcium-magnesium-ammonium-phosphate stones, myasthenia gravis, atrioventricular block, liver cirrhosis with ascites, children under 18 years of age, lactose intolerance, lactase deficiency or glucose-galactose malabsorption (due to presence of lactose in the composition).

Side Effects

The incidence of adverse reactions cannot be determined based on the available data.

Gastrointestinal disorders: unstable stool and diarrhea, which resolve on their own when the dose of the drug is reduced.

From the immune system: allergic reactions.

If any of the side effects listed in the instructions get worse, or you notice any other side effects not listed in the instructions, tell your doctor.

Interaction

When taking magnesium-containing drugs simultaneously with iron, sodium fluoride and tetracyclines, absorption of the latter may decrease. In addition, aminoquinolines, quinidine, and penicillamine should not be administered simultaneously with magnesium preparations. Therefore, these drugs should be taken at intervals of 2-3 hours. Oral contraceptives, diuretics, muscle relaxants, glucocorticosteroids, insulin reduce the effect of the drug.

Magnesium should be used with caution if you are taking medications that contain magnesium, such as antacids or laxatives, or potassium-sparing diuretics or medications that contain calcium. When used simultaneously with drugs containing aluminum, the absorption of aluminum in the body may be increased.

Magnesium should be used with caution when used concomitantly with digitalis preparations as concurrent use may interfere with the absorption of digitalis preparations.

Some antibiotics (aminoglycosides), cisplatins and cyclosporine A may lead to increased excretion of magnesium.

Some diuretics (thiazides and furosemide), cetuximab and erlotinib, proton pump inhibitors (omeprazole and pantoprazole), foscarnet, pentamidine, rapamycin and amphotericin B may cause magnesium deficiency and thus reduce the effect of Magnerot®.

Overdose

With normal kidney function, oral magnesium does not cause toxic reactions. Magnesium poisoning can develop in kidney failure. Toxic effects mainly depend on serum magnesium concentration.

Symptoms: decreased blood pressure, nausea, vomiting, depression, slowed reflexes, respiratory depression, coma, cardiac arrest, anuric syndrome.

Treatment: rehydration, forced diuresis; in case of renal failure, hemodialysis or peritoneal dialysis is necessary.

Storage conditions

At a temperature not exceeding 25 °C.
Keep out of the reach of children.

Shelf life

5 years.
Do not use after expiration date.

Manufacturer

Peak-Pharma Lek, Russia