Lyfferon lyophilizate 1 mln.me 5 pcs

Adults as a part of complex therapy:

• acute viral hepatitis B – moderate and severe forms at the beginning of jaundice period until the 5th day of jaundice (in later periods administration of the drug is less effective;
• acute prolonged hepatitis B and C, chronic active hepatitis B and C including delta agent
• Viral (influenza, adenovirus, enterovirus, herpes, parotitis), viral-bacterial and mycoplasma meningoencephalitis. The drug is most effective in the first 4 days of the disease;
• Kidney cancer stage IV, hairy cell leukemia, malignant skin lymphoma (mycosis fungoides, primary reticulosis, rstikulosarcomatosis), Kaposi sarcoma. Basal cell and squamous cell skin cancer, keratoacanthoma. chronic myeloleukemia, Laigerhans cell histiocytosis, subleukemic myelosis, essential thrombocythemia.
• Viral conjunctivitis, keratoconjunctivitis. keratitis, keratoiridocyclitis,keratouveitis.

In case of children from 1 year old in the complex therapy:

• acute lymphoblastic leukemia in the period of remission after the end of inductive chemotherapy (for 4-5 months of remission);
• juvenile respiratory papillomatosis of the larynx, starting the day after removal of papillomas.

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Active ingredient

Interferon alfa-2b

Composition

Lyophilisate for preparation of solutions for intramuscular, subconjunctival injection and eye drops in the form of powder or porous mass of white, hygroscopic.

Associates:

Sodium chloride – 9.2 mg,

sodium hydrophosphate dodecahydrate (sodium phosphate disodium 12-water) – 2.74 mg,

sodium dihydrophosphate dihydrate (sodium phosphoric acid single-substituted 2-water) – 0.37 mg,

dextran with m.m. 30000 to 40000 (in the form of “Reonopolyglucin” solution containing 100 mg/1 ml of dextran in 0.9% sodium chloride solution) – 8 mg,

sorbitol (D-sorbitol) – 3 mg,

urea (urea) – 0.1 mg.

How to take, the dosage

Liffcron® is administered by injection/m, in or under the lesion, subconjunctival or topically. Immediately before use the contents of the ampoule (vial) is dissolved in water for injection or in 0.9% sodium chloride solution (1 ml for intravenous and focal injection, 5 ml for subconjunctival and local injection). The drug solution should be colorless, with weak opalescence, without precipitate and foreign inclusions. Dissolution time should be about 10 minutes.

Interaction

Interferon alfa-2b can reduce cytochrome P450 activity and therefore interfere with the metabolism of cimetidine, phenytoin, dipyridamole, theophylline, diazepam, propranolol, warfarin, some cytostatics. It may intensify neurotoxic, myelotoxic or cardiotoxic effects of drugs prescribed earlier or simultaneously with it.

Special Instructions

In case of severe adverse reactions or persistence for a long time, at the discretion of the physician, temporary dose reduction (when platelet count is less than 50,000 cells per 1 µl, absolute neutrophil count is less than 750 cells per 1 µl) or treatment interruption (when platelet count is less than 25,000 cells per 1 µl, absolute neutrophil count is less than 500 cells per 1 µl) is allowed.

Contraindications

• Hypersensitivity to the ingredients of the drug
• severe forms of allergic diseases
• pregnancy
• lactation period
  

Side effects

When parenteral administration of the drug chills, fever, fatigue, headache, malaise, flu-like syndrome are possible. These side effects are partially controlled with paracetamol or indomethacin.