Live rubella culture vaccine, 0.5 ml/dose
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A live attenuated vaccine for the prevention of rubella. The attenuated vaccine virus (strain Wistar RA 27/3M) is cultured on human diploid cells.
Specific immunity develops within 15 days after vaccination and is reported to last for at least 20 years.
Indications
Prevention of rubella in children, regardless of sex, starting at 12 months of age; prevention of rubella in unvaccinated or not rubella-ill girls of prepubertal and postpubertal age and women of childbearing age.
Active ingredient
Vaccine to prevent rubella
Composition
A vaccine dose contains at least 1,000 TCD 50 of rubella virus.
How to take, the dosage
- Application under the “National calendar of preventive vaccinations:
- first vaccination at 12 months
- second vaccination at 6 years
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- Single vaccination of girls and non-pregnant women of childbearing age who have neither been vaccinated nor had rubella for prevention of fetal congenital rubella.
- Single vaccination of young boys and men for epidemiological reasons in limited groups.
The vaccine must be diluted only with the solvent provided (water for injection), using a sterile syringe and needle with gentle shaking. The dilution time of the vaccine is 1 minute. Dissolved drug is a clear liquid of light yellow color.
It is recommended to use the vaccine immediately after dilution. Dissolved vaccine in multi-dose packaging can be stored in a dark place at 2-8 ° C for no more than 8 hours.
A single dose (0.5 ml) should be injected deep subcutaneously in the shoulder area.
Interaction
Vaccines
The rubella vaccine can be administered simultaneously (on the same day) with vaccines against pertussis, diphtheria, tetanus, polio (live and inactivated), hepatitis B, measles, epidemic parotitis in different syringes or one month after the previous vaccination.
Immunoglobulins and blood products
After the introduction of blood products (immunoglobulin, plasma, etc.) it is recommended to administer the vaccine not earlier than 3 months. After administration of rubella vaccine blood products can be administered not earlier than in 2 weeks. If immunoglobulin has to be given earlier than this, the rubella vaccination should be repeated after 3 months.
In the presence of rubella antibodies in the serum, vaccination should not be repeated.
Tuberculin
Tuberculin tests are recommended before or 4-6 weeks after rubella vaccine administration.
Special Instructions
Women of childbearing age should use effective contraception for at least 2 months after vaccination.
The use of this vaccine in women in the early stages of a pregnancy not yet established is not an indication for termination of that pregnancy.
The decision to vaccinate a baby born of an HIV-infected mother, and the determination of the child’s immune status, will be delayed until the baby is 9-10 months old, since maternal IgG which has penetrated the placenta can persist in the blood up to 14 months of age. If the child is found to be HIV-infected after this age, a panel of doctors will decide whether or not to vaccinate the child. If the child is found to be uninfected, a regular vaccination is administered.
The rubella (live) vaccine can be given along with other vaccines. The most widely used combination vaccine is for the prevention of measles, mumps and rubella.
Due to possible inactivation of the vaccine strain by serum antibodies, vaccination is not carried out for 6 weeks (if possible, for 3 months) after administration of immunoglobulins or other blood products, and also after the vaccine administration no immunoglobulins are used for 2 weeks.
The tuberculin test may be false-negative for some time after vaccination.
Contraindications
- Pregnancy
- Acute infectious and noninfectious diseases, exacerbation of chronic diseases vaccination should not be carried out earlier than 1 month after recovery.
- Immunodeficiency states, malignant blood diseases and tumors. If immunosuppressants and radiation therapy are prescribed, vaccination should be carried out 12 months after the end of treatment.
- Severe reaction (fever above 40 ° C, swelling, hyperemia >8 cm in diameter at the injection site) or a complication to the previous dose of the vaccine.
Note:
HIV-infected children may be immunized with rubella vaccine.
Side effects
The injection site may develop transient hyperemia, swelling and thickening accompanied by pain.
Weight | 0.040 kg |
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Shelf life | 2 years |
Conditions of storage | The vaccine is stored and transported at +2 ° C to +8 ° C in a place protected from light. Freezing is not allowed. |
Manufacturer | Microgen NPO, Russia |
Medication form | solution for injection |
Brand | Microgen NPO |
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