Livarol, vaginal suppositories 400 mg 5 pcs

The active ingredient is ketoconazole, a derivative of imidazoldioxolane.

It has fungicidal and fungostatic effect against dermatophytes (Trichophyton spr., Eridermophyton floccosum, Microsporum spr.) and yeasts (Candida spr., Pityrosporum spr.).

The mechanism of action is inhibition of ergosterol biosynthesis and changing lipid composition of the fungal membrane.

The drug is active against staphylococci and streptococci.

Pharmacokinetics

Systemic absorption with intravaginal use is negligible.

Indications

Treatment of acute and chronic recurrent vaginal candidiasis.

Prevention of the occurrence of fungal infections of the vagina with reduced body resistance and during treatment with antibacterial agents and other drugs that disrupt the normal microflora of the vagina.

Pharmacological effect

The active substance is ketoconazole, an imidazoledioxolane derivative.

It has a fungicidal and fungostatic effect against dermatophytes (Trichophyton spp., Eridermophyton floccosum, Microsporum spp.) and yeast (Candida spp., Pityrosporum spp.).

The mechanism of action is to inhibit the biosynthesis of ergosterol and change the lipid composition of the fungal membrane.

The drug is active against staphylococci and streptococci.

Pharmacokinetics

Systemic absorption after intravaginal use is negligible.

Active ingredient

Ketoconazole

Composition

Active ingredient:

Ketoconazole – 400 mg;

Excipients:

Butylated hydroxyanisole.

Suppository base:

Macrogol 1500 (polyethylene oxide 1500),

Macrogol 400 (polyethylene oxide 400) – sufficient quantity to obtain a suppository weighing 3.0 g.

Contraindications

Hypersensitivity to the components of the drug. Pregnancy (1st trimester).

With caution: pregnancy (II-III trimester), lactation, children under 12 years of age.

Side Effects

Hyperemia and irritation of the vaginal mucosa, vaginal itching.

Allergic reactions: skin rash, urticaria.

Interaction

When using Livarol® vaginal suppositories 400 mg. Negative interactions with other drugs are not known and should not be expected, since the resorption capacity of ketoconazole is low.

Storage conditions

In a dry place, protected from light, at a temperature not exceeding 25 °C

Shelf life

2 years

Manufacturer

Nizhpharm JSC, Russia