Lidocaine, eye drops 2% 5 ml

Lidocaine is a local anesthetic and antiarrhythmic drug.

The antiarrhythmic activity is due to inhibition of phase 4 (diastolic depolarization) in Purkinje fibers, reduction of automaticity, suppression of ectopic foci of excitation. The rate of rapid depolarization (phase 0) is not affected or slightly reduced.

increases membrane permeability to potassium ions, accelerates the process of repolarization and shortens the action potential.

After injection into the conjunctival sac, the local anesthetic effect is achieved in 2-3 minutes and lasts for at least 6-8 minutes.

Indications

In ophthalmology:

Active ingredient

Composition

The eye drops are 2% clear, colorless or slightly colored.

1 mllidocaine hydrochloride 20 mg

Associated substances:

benzetonium chloride,

sodium chloride,

water d/i.

How to take, the dosage

Two drops of the solution are injected into the conjunctival sac 2-3 times at intervals of 30-60 seconds immediately before the examination or surgery.

Interaction

It is undesirable to combine lidocaine with the following drugs:

With beta-adrenoblockers because of increased toxic properties of lidocaine, with digitoxin because of weakened cardiotonic effect, with curare-like drugs because muscle relaxation is increased.
It is not rational to prescribe lidocaine together with aymalin, amiodarone, verapamil or quinidine due to increased cardiodepressant effect.

The combined use of lidocaine and novocainamide may cause CNS agitation and hallucinations.
When hexenal or thiopental sodium are administered intravenously against the background of lidocaine action, respiratory depression may occur.

MoA inhibitors may increase local anesthetic effect of lidocaine.
If lidocaine and polymyxine are administered simultaneously, there may be increased inhibitory effects on neuromuscular transmission, so the patient’s respiratory function should be monitored in this case.

The simultaneous use of lidocaine with hypnotics or sedatives may increase their CNS depressant effect. When lidocaine is administered intravenously to patients taking cimetidine, such unwanted effects as stunned state, somnolence, bradycardia, parasthesias, etc. may occur.

This is due to increased plasma levels of lidocaine, which is explained by the release of lidocaine from binding to blood proteins, as well as the slowing of its inactivation in the liver. If combination therapy with these drugs is necessary, the dose of lidocaine should be reduced.

Pharmaceutical interactions

The following drugs increase serum concentrations of lidocaine when used concomitantly: aminasine, cimetidine, propranolol, pethidine, bupivacaine, quinidine, disopyramide, amitriptyline, imipramine, nortriptyline.

Contraindications

The drug should be used with caution in children.

Side effects

Local reactions: a mild burning sensation, which disappears as the anesthetic effect develops (within 1 minute).

Pregnancy use

The drug should be used with caution during pregnancy and lactation.
It is unknown whether lidocaine is excreted with the breast milk. Caution should be exercised when prescribing the drug to a nursing mother.

In lactation, the use of the drug is possible after careful assessment of the expected benefit to the mother and the potential risk to the infant.

Per pediatric use

The drug should be used with caution in children.

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