Lidase, lyophilizate 1280 me 10 pcs

Active ingredient

Hyaluronidase

Interaction

Improves absorption of drugs administered subcutaneously or intramuscularly, enhances the effect of local anesthetics.

Directions for use

In cicatricial lesions administer 64 units (1 ml) daily or every other day (10-20 injections in total) subcutaneously (under the scar tissue) or intramuscularly (near the lesion).

In case of traumatic lesions of nerve plexuses and peripheral nerves the drug is injected subcutaneously in the area of the affected nerve (64 units in procaine solution) every other day; 12-15 injections for the course. The course of treatment is repeated if necessary.

When used in ophthalmic practice the drug is administered subconjunctival – 0.3 ml, parabulbar 0.5 ml as well as by electrophoresis.

Patients with pulmonary tuberculosis with productive character of inflammation are prescribed in the complex therapy to increase the concentration of antibacterial drugs in the lesion as injections and/or inhalations. Inhalations shall be performed once daily using 5 ml of solution (320 UU). A course of treatment consists of 20-25 inhalations. If necessary, repeat courses at intervals of 1.5-2 months.

In the form of dressings soaked in the drug solution. To prepare the solution every 64 units are dissolved in 10 ml of sterile 0.9% sodium chloride solution or boiled water at room temperature. A sterile dressing folded in 4-5 layers is moistened with this solution, applied to the affected area, covered with wax paper and fixed with a soft dressing. The dose depends on the affected area
(32-64 UU/ sq.cm). The average dose is 320 UU per bandage. The dressing is applied daily for
15-18 hours for 15-60 days. With long-term use, a break of 3 to 4 days is taken every 2 weeks.

In case of electrophoresis the solution of 320 UU is dissolved in 64 ml of distilled water, 2-3 drops of 0.1% hydrochloric acid solution are added and the solution is applied to the affected area for 20-30 minutes using an anode. The course of treatment is 15-20 sessions. Applicative dosing mode can be alternated with electrophoresis. The prepared solution should be used within 24 hours.

Contraindications

Hypersensitivity, acute infectious and inflammatory diseases, recent hemorrhage.

For inhaled administration – pulmonary tuberculosis with marked respiratory failure; pulmonary hemorrhage, hemoptysis; malignant neoplasms, fresh vitreous hemorrhage. Concomitant administration of estrogens.

With caution: pregnancy, lactation.

Side effects

Allergic reactions; with prolonged use – local irritation.