Lidase, lyophilizate 1280 me 10 pcs

Indications

Burn, traumatic, postoperative scars; long-term non-healing ulcers
(including radiation); Dupuytren’s contracture; joint stiffness, joint contractures (after inflammatory processes, injuries), osteoarthritis, ankylosing spondylitis, severe diseases of the lumbar discs; chronic tendovaginitis, scleroderma (skin manifestations), superficial soft tissue hematoma; preparation for skin plastic surgery for scar tissue.

Pharmacological effect

An enzyme preparation isolated from the testes of cattle.

Active ingredient

Hyaluronidase

Contraindications

Hypersensitivity, acute infectious and inflammatory diseases, recent hemorrhages.

For inhalation administration – pulmonary tuberculosis with severe respiratory failure; pulmonary hemorrhage, hemoptysis; malignant neoplasms, fresh hemorrhage into the vitreous body. Concomitant use of estrogens.

With caution: pregnancy, lactation period

Side Effects

Allergic reactions; with long-term use – local irritating effect.

Interaction

Improves the absorption of drugs administered subcutaneously or intramuscularly, enhances the effect of local anesthetics.

Recommendations for use

For scar lesions, 64 UE (1 ml) is administered subcutaneously (under the scar tissue) or intramuscularly (near the site of the lesion) daily or every other day (10-20 injections in total).

For traumatic lesions of the nerve plexuses and peripheral nerves, inject subcutaneously into the area of ​​the affected nerve (64 UE in procaine solution) every other day; per course – 12-15 injections. The course of treatment is repeated if necessary.

When used in ophthalmic practice, the drug is administered subconjunctivally – 0.3 ml, parabulbarly – 0.5 ml, and also by electrophoresis.

Patients with pulmonary tuberculosis with a productive nature of inflammation are prescribed in complex therapy to increase the concentration of antibacterial drugs in the lesions in the form of injections and/or inhalations. Inhalations are carried out once daily using 5 ml of solution (320 CU). The course of treatment consists of 20-25 inhalations. If necessary, repeat courses are carried out at intervals of 1.5-2 months.

In the form of bandages soaked in a solution of the drug. To prepare the solution, every 64 units are dissolved in 10 ml of sterile 0.9% sodium chloride solution or boiled water at room temperature. A sterile bandage folded in 4-5 layers is moistened with this solution, applied to the affected area, covered with wax paper and secured with a soft bandage. The dose depends on the affected area
(32-64 UE/sq.cm), on average – 320 UE per bandage. The bandage is applied daily to the
15-18 hours for 15-60 days. With long-term use, take a break for 3-4 days every 2 weeks.

When used by electrophoresis, 320 UE is dissolved in 64 ml of distilled water, 2-3 drops of 0.1% hydrochloric acid solution are added and injected from the anode onto the affected area for 20-30 minutes. The course of treatment is 15-20 sessions. The application dosing regimen can be alternated with electrophoresis. The prepared solution must be used within 24 hours.

Manufacturer

Microgen NPO, Russia