Levomycetin, tablets 500 mg, 10 pcs.

A broad spectrum antibiotic. The mechanism of antimicrobial action is connected with disruption of microbial protein synthesis. It has bacteriostatic action.

Active against Gram-positive bacteria: Staphylococcus spp., Streptococcus spp.; against Gram-negative bacteria: Neisseria gonorrhoeae, Neisseria meningitidis, Escherichia coli, Haemophilus influenzae, Salmonella spp, Shigella spp., Klebsiella spp., Serratia spp., Yersinia spp., Proteus spp., Rickettsia spp.; also active against Spirochaetaceae, some major viruses.

Chloramphenicol is active against strains resistant to penicillin, streptomycin, sulfonamides.

The resistance of microorganisms to chloramphenicol develops relatively slowly.

Indications

For oral administration: infectious and inflammatory diseases caused by microorganisms sensitive to chloramphenicol, including: typhoid fever, paratyphoid fever, dysentery, brucellosis, tularemia, whooping cough, typhus and other rickettsioses; trachoma, pneumonia, meningitis, sepsis, osteomyelitis.

For external use: purulent skin lesions, boils, long-term non-healing trophic ulcers, second and third degree burns, cracked nipples in nursing women.

For local use in ophthalmology: inflammatory eye diseases.

Pharmacological effect

Broad-spectrum antibiotic. The mechanism of antimicrobial action is associated with a violation of the synthesis of microbial proteins. Has a bacteriostatic effect.

Active against gram-positive bacteria: Staphylococcus spp., Streptococcus spp.; gram-negative bacteria: Neisseria gonorrhoeae, Neisseria meningitidis, Escherichia coli, Haemophilus influenzae, Salmonella spp., Shigella spp., Klebsiella spp., Serratia spp., Yersinia spp., Proteus spp., Rickettsia spp.; also active against Spirochaetaceae and some large viruses.

Chloramphenicol is active against strains resistant to penicillin, streptomycin, and sulfonamides.

Resistance of microorganisms to chloramphenicol develops relatively slowly.

Special instructions

Chloramphenicol is not used in newborns, because the development of “gray syndrome” is possible (flatulence, nausea, hypothermia, gray-blue skin color, progressive cyanosis, dyspnea, cardiovascular failure).

Use with caution in patients who have previously received treatment with cytotoxic drugs or radiation therapy.

With simultaneous intake of alcohol, a disulfiram-like reaction may develop (skin hyperemia, tachycardia, nausea, vomiting, reflex cough, convulsions).

During treatment, systematic monitoring of peripheral blood patterns is necessary.

Active ingredient

Chloramphenicol

Composition

Pills
1 tab.
chloramphenicol
500 mg

Contraindications

Blood diseases, severe liver dysfunction, deficiency of the enzyme glucose-6-phosphate dehydrogenase, skin diseases (psoriasis, eczema, fungal diseases); pregnancy, lactation, children up to 4 weeks of age (newborns), hypersensitivity to chloramphenicol, thiamphenicol, azidamphenicol.

Side Effects

From the hematopoietic system: thrombocytopenia, leukopenia, agranulocytosis, aplastic anemia.

From the digestive system: nausea, vomiting, diarrhea, flatulence.

From the central nervous system and peripheral nervous system: peripheral neuritis, optic neuritis, headache, depression, confusion, delirium, visual and auditory hallucinations.

Allergic reactions: skin rash, urticaria, angioedema.

Local reactions: irritant (for external or local use).

Interaction

With the simultaneous use of chloramphenicol with oral hypoglycemic drugs, an increase in the hypoglycemic effect is observed due to the suppression of the metabolism of these drugs in the liver and an increase in their concentration in the blood plasma.

When used simultaneously with drugs that inhibit bone marrow hematopoiesis, there is an increased inhibitory effect on the bone marrow.

When used simultaneously with erythromycin, clindamycin, lincomycin, a mutual weakening of the effect is observed due to the fact that chloramphenicol can displace these drugs from the bound state or prevent their binding to the 50S subunit of bacterial ribosomes.

When used simultaneously with penicillins, chloramphenicol counteracts the bactericidal effect of penicillin.

Chloramphenicol suppresses the cytochrome P450 enzyme system, therefore, when used simultaneously with phenobarbital, phenytoin, warfarin, a weakening of the metabolism of these drugs, a slower elimination and an increase in their concentration in the blood plasma are observed.

Storage conditions

In a dry place, protected from light, at a temperature not exceeding 30 °C.

Manufacturer

Irbitsky Chemical Plant, Russia