Levomycetin, 3% 25 ml

Pharmacotherapeutic group

Antibiotic

ATX code: D06AX02

Pharmacological Action

The active ingredient of the drug is chloramphenicol – a broad spectrum antibiotic with high antibacterial activity against pathogens of wound infection and various forms of pyo-inflammatory processes. Chloramphenicol is a bacteriostatic antibiotic that disrupts protein synthesis in a microbial cell (it has good lipophilicity, penetrates through the cell membrane of bacteria and reversibly binds to the substance 50S of bacterial ribosomes, where amino acid transfer to the growing peptide chains is delayed, which leads to disruption of protein synthesis). Active against most strains of gram-positive and gram-negative microorganisms resistant to penicillin, tetracyclines, sulfonamides. It promotes cleansing and healing of burn wounds and trophic ulcers, accelerates epithelialization. Resistance of microorganisms to chloramphenicol develops relatively slowly.

Indications

Skin infections, burns, eczemaBacterial skin infections caused by susceptible microorganisms, including infected burns (superficial and limited deep), bedsores, trophic ulcers, furuncles

Active ingredient

Chloramphenicol

Composition

Active ingredient:

Chloramphenicol (levomycetin) – 3 g

Particulate matter:

Ethanol (ethyl alcohol) 70% – up to 100 ml

How to take, the dosage

Outwardly, the affected areas are treated with a cotton swab soaked in the solution several times a day. Duration of treatment is according to indications depending on the nature and localization of the affected area. If after treatment there is no improvement or the symptoms worsen or new symptoms appear, consult a physician.

Interaction

When concomitant use with erythromycin, clindamycin, lincomycin there is a mutual weakening of action due to the fact that chloramphenicol may displace these drugs from the bound state or prevent their binding to the substance 50S of bacterial ribosomes. Reduces the antibacterial effect of penicillins and cephalosporins. If you are using the above or other drugs (including over-the-counter medications), consult your physician before using this medication.

Directions for use

The drug is contraindicated in pregnancy and during breast-feeding.

Special Instructions

During treatment, systematic monitoring of peripheral blood counts is necessary. Simultaneous administration of ethanol may cause disulfiram-like reactions (skin hyperemia, tachycardia, nausea, vomiting, reflex cough, seizures). Use the drug only according to those indications, that method of administration and in those doses specified in the instructions.

Synopsis

Transparent colorless or yellowish liquid with a characteristic odor of alcohol

Contraindications

Individual intolerance, bone marrow suppression, acute intermittent porphyria, glucose-6-phosphate dehydrogenase deficiency, hepatic and renal insufficiency, skin diseases (eczema, psoriasis, fungal lesions), period of infancy (up to 4 weeks) Caution Early childhood, previous treatment with cytostatic drugs or radiation therapy

Side effects

Allergic reactions: skin rash, angioedema. Blood organs: rarely – thrombocytopenia, erythropenia, aplastic anemia, agranulocytosis, reticulocytopenia, leukopenia, granulocytopenia. If any of the side effects listed in the instructions worsen, or if you notice any other side effects not listed in the instructions, tell your doctor.

Overdose

To date, no cases of drug overdose have been reported.

Pregnancy use

The drug is contraindicated in pregnancy and during breast-feeding.

Similarities

Levomycetin Actitab