Levomycetin Reneval, 1% alcohol 25 ml

Pharmacotherapeutic group: antibiotic.

The ATX code: D06AX02

Pharmacological properties

Pharmacodynamics
The active ingredient of the drug is chloramphenicol – a broad spectrum antibiotic with high antibacterial activity against the causative agent of wound infection and various forms of pyo-inflammatory processes.
Chloramphenicol is bacteriostatic antibiotic that disrupts protein synthesis in microbial cell (possessing good lipophilicity, penetrates through bacterial cell membrane and reversibly binds with 50S subunit of bacterial ribosomes where amino acid transfer to growing peptide chains is delayed that leads to disruption of protein synthesis). It is active against Gram-positive (Staphylococcus spp., Streptococcus spp.) and Gram-negative cocci (Neisseria gonorrhoeae, N. meningitidis), bacteria (Escherichia coli, Haemophilus influenzae, Salmonella spp, Shigella spp., Klebsiella spp., Serratia spp., Yersinia spp., Proteus spp.), rickettsia, spirochetes, some major viruses. The drug is active against strains resistant to penicillin, tetracyclines, streptomycin, sulfonamides. Microbial resistance to chloramphenicol develops relatively slowly. It promotes purification and healing of burn purulent wounds and trophic ulcers and accelerates epithelialization.

Pharmacokinetics
The degree of systemic action when using the drug externally has not been studied.

Indications

Active ingredient

Composition

The active ingredient:
Chloramphenicol – 0,25 g
– 1 g
– 3 g
– 5 g
Auxiliary substance:
ethanol (ethyl alcohol) 70%
–
to 100 ml

How to take, the dosage

Interaction

Special Instructions

Systematic monitoring of peripheral blood counts is necessary during treatment. Caution is used in patients who have previously received treatment with cytostatic drugs or radiation therapy. Simultaneous use of ethanol may cause disulfiram-like reactions (skin hyperemia, tachycardia, nausea, vomiting, reflex cough, convulsions).

Influence on driving and operating machinery
The drug does not affect the speed of neuromuscular conduction, in the recommended doses it can be used by persons operating vehicles and other mechanisms.

Synopsis

Contraindications

Individual intolerance, pregnancy and lactation, suppression of bone marrow hematopoiesis, acute intermittent porphyria, glucose-6-phosphate dehydrogenase deficiency, hepatic, renal failure, skin diseases (fungal diseases, psoriasis, eczema), period of infancy (up to 4 weeks).

Cautions

Early childhood; prior treatment with cytostatic drugs or radiation therapy.

Side effects

Overdose

Pregnancy use

Similarities