Levomycetin, eye drops 0.25% 5 ml

A broad spectrum antibiotic. The mechanism of antimicrobial action is connected with disruption of microbial protein synthesis. It has bacteriostatic action.

Active against Gram-positive bacteria: Staphylococcus spp., Streptococcus spp.; against Gram-negative bacteria: Neisseria gonorrhoeae, Neisseria meningitidis, Escherichia coli, Haemophilus influenzae, Salmonella spp, Shigella spp., Klebsiella spp., Serratia spp., Yersinia spp., Proteus spp., Rickettsia spp.; also active against Spirochaetaceae, some major viruses.

Chloramphenicol is active against strains resistant to penicillin, streptomycin, sulfonamides.

The resistance of microorganisms to chloramphenicol develops relatively slowly.

Indications

bacterial eye infections, incl. conjunctivitis, keratitis, keratoconjunctivitis, blepharitis, episcleritis, scleritis

Pharmacological effect

Broad-spectrum antibiotic. The mechanism of antimicrobial action is associated with a violation of the synthesis of microbial proteins. Has a bacteriostatic effect.

Active against gram-positive bacteria: Staphylococcus spp., Streptococcus spp.; gram-negative bacteria: Neisseria gonorrhoeae, Neisseria meningitidis, Escherichia coli, Haemophilus influenzae, Salmonella spp., Shigella spp., Klebsiella spp., Serratia spp., Yersinia spp., Proteus spp., Rickettsia spp.; also active against Spirochaetaceae and some large viruses.

Chloramphenicol is active against strains resistant to penicillin, streptomycin, and sulfonamides.

Resistance of microorganisms to chloramphenicol develops relatively slowly.

Special instructions

Due to high toxicity, it is not recommended to be used unnecessarily for the treatment and prevention of common infections, colds, flu, pharyngitis, and bacterium carriage.

Severe complications from the hematopoietic system are usually associated with the use of large doses (more than 4 g/day) for a long time. During treatment, systematic monitoring of peripheral blood patterns is necessary.

In the fetus and newborns, the liver is not developed enough to bind chloramphenicol, and the drug can accumulate in toxic concentrations and lead to the development of “gray syndrome”, so children in the first months of life are prescribed the drug only for health reasons.

Prescribe with caution to patients who have previously received treatment with cytotoxic drugs or radiation therapy.

Active ingredient

Chloramphenicol [D,L]

Composition

1 ml eye drops 0.25% contain:

chloramphenicol – 2.5 mg:

Excipients:

boric acid – 20 mg,

purified water – up to 1 ml.

Pregnancy

During pregnancy, it is possible if the expected effect of therapy outweighs the potential risk to the fetus (adequate and strictly controlled studies on use during pregnancy have not been conducted; the ability of chloramphenicol to penetrate the placenta should be taken into account).

Contraindications

Hypersensitivity, diseases of the hematopoietic organs, acute intermittent porphyria, severe renal and liver dysfunction, deficiency of glucose-6-phosphate dehydrogenase, psoriasis, eczema, fungal skin diseases, neonatal period (up to 4 weeks) and early childhood.

Side Effects

Local allergic reactions.

Interaction

To prevent an increase in the inhibitory effect on hematopoiesis, combined use with sulfonamide drugs is not recommended.

Overdose

Symptoms from the drug can be: “gray syndrome” in premature babies and newborns when treated with high doses (the reason for the development is the accumulation of chloramphenicol, due to the immaturity of liver enzymes, and its direct toxic effect on the myocardium) – bluish-gray skin color, low body temperature, irregular breathing, lack of reactions, cardiovascular failure.

Storage conditions

At a temperature not higher than 15 °C.
Keep out of the reach of children.
Store in original packaging.

Shelf life

2 years

Manufacturer

Lecco CJSC, Russia