Levomycetin, eye drops 0.25% 5 ml

A broad spectrum antibiotic. The mechanism of antimicrobial action is connected with disruption of microbial protein synthesis. It has bacteriostatic action.

Active against Gram-positive bacteria: Staphylococcus spp., Streptococcus spp.; against Gram-negative bacteria: Neisseria gonorrhoeae, Neisseria meningitidis, Escherichia coli, Haemophilus influenzae, Salmonella spp, Shigella spp., Klebsiella spp., Serratia spp., Yersinia spp., Proteus spp., Rickettsia spp.; also active against Spirochaetaceae, some major viruses.

Chloramphenicol is active against strains resistant to penicillin, streptomycin, sulfonamides.

The resistance of microorganisms to chloramphenicol develops relatively slowly.

Indications

Bacterial eye infections, including conjunctivitis, keratitis, keratoconjunctivitis, blepharitis, episcleritis, scleritis

Active ingredient

Composition

1 ml of 0.25% eye drops contain:

Chloramphenicol – 2.5 mg:

Harmful substances:

Boric acid – 20 mg,

Purified water – up to 1 ml.

How to take, the dosage

Interaction

To prevent increased suppressive effects on blood production, co-administration with sulfonamides is not recommended.

Special Instructions

Due to the high toxicity it is not recommended to use unnecessarily for the treatment and prevention of trivial infections, colds, influenza, pharyngitis, bacturia.

Severe complications of the hematopoietic system, as a rule, are associated with the use of high doses (more than 4 g/day) for a long time. Systematic monitoring of peripheral blood counts is necessary during treatment.

In fetus and newborn children the liver is not developed enough to bind chloramphenicol and the drug may accumulate in toxic concentration and lead to “gray syndrome”, therefore in children in the first months of life the drug is prescribed only with vital signs.

Patients who have previously been treated with cytostatic drugs or radiation therapy are used with caution.

Contraindications

Hypersensitivity, blood disorders, acute intermittent porphyria, marked renal and hepatic dysfunction, glucose-6-phosphate dehydrogenase deficiency, psoriasis, eczema, fungal skin diseases, period of infancy (up to 4 weeks) and early childhood.

Side effects

Local allergic reactions.

Overdose

Pregnancy use

In pregnancy it is possible if the expected effect of therapy exceeds the potential risk to the fetus (adequate and strictly controlled studies on use during pregnancy have not been conducted, the ability of chloramphenicol to penetrate the placenta should be taken into account).

Similarities